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Catecholamine Secreting Glomus Tumor Detected by Iodine-123-MIBG Scintigraphy

Departments of Nuclear Medicine and Radiology, Institute for Pathology and Medical Clinic, University of Tübingen, Tübingen, Germany
Institute for Diagnostic Nuclear Medicine, Freiburg, Germany

Correspondence: For correspondence or reprints contact: Peter Reuland, MD, Institute for Nuclear Medicine, Schwabentorplatz 6, 79098 Freiburg, Germany.

ABSTRACT

We report the case of a 41-yr-old woman who presented with arterial hypertension and tinnitus in the right ear synchronous with pulse. She had previously undergone surgery for suspected pheochromocytoma without positive therapeutic effect. CT and MRI revealed a homogenous tumor with contrast enhancement in the right hypotympanon and foramen jugulare, and [¹²³I]metaiodobenzylguanidine (MIBG) scintigraphy demonstrated strong tracer uptake in the same area. Selective venous sampling of catecholamines in the ipsilateral jugular vein confirmed the tumor to have originated from hormone production.

Key Words: iodine-123-MIGB • endocrine active glomus tumor • pheochromocytoma