| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | RSS | TABLE OF CONTENTS |
|
|
|
||||||||
|
||||||||||
Departments of Medicine and Endocrinology and the Diabetes Centre, Royal Adelaide Hospital, Adelaide, South Australia
Correspondence: For correspondence contact: Professor M. Horowitz, Department of Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, South Australia 5000.
ABSTRACT
The aims of this study were to determine in early noninsulin-dependent diabetes mellitus (NIDDM): (a) the prevalence of disordered gastric emptying of glucose; (b) the relationship between the blood glucose response to an oral glucose load and gastric emptying; and (c) the relationship between appetite and gastric emptying. Methods: Sixteen patients (ages 39–79 yr) with recently diagnosed NIDDM consumed 350 ml water containing 75 g glucose and 99mTc-sulfur colloid while sitting in front of a gamma camera. Blood glucose concentrations were monitored immediately before and after the drink. Hunger and fullness were evaluated using visual analog scales. The results were compared to those obtained in 13 normal subjects of similar age and body mass index. All patients and control subjects were white and non-Hispanic. Results: Gastric emptying was slightly slower in the NIDDM patients when compared to the control subjects (retention at 180 min 15.9 ± 2.3% versus 3.8 ± 1.0%, p < 0.001), but there was no significant difference in the 50% emptying time between the two groups. In the NIDDM patients, there was an inverse relationship between the magnitude of the increase in the blood glucose concentration and gastric emptying, e.g., between the area under the curve for blood glucose from 0–60 min and the intragastric retention of the drink at 60 min (r = 
0.60, p < 0.05). In the NIDDM patients, fullness was greater (p < 0.005) both before and after the drink, and the score for hunger at 30 min was inversely related to the rate of gastric emptying (r = 0.52, p < 0.05). Conclusion: In patients with early NIDDM, gastric emptying of 75 g glucose is similar to that of normal subjects and is a significant determinant of the glycemic response.
Key Words: gastric emptying • appetite • glycemic control • autonomic neuropathy
This article has been cited by other articles:
|
|
 |
|
  J. E. Stevens, S. Doran, A. Russo, D. O'Donovan, C. Feinle-Bisset, C. K. Rayner, M. Horowitz, and K. L. Jones Effects of intravenous fructose on gastric emptying and antropyloroduodenal motility in healthy subjects Am J Physiol Gastrointest Liver Physiol, December 1, 2009; 297(6): G1274 - G1280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. M. Brennan, K. L. Feltrin, N. S. Nair, T. Hausken, T. J. Little, D. Gentilcore, J. M. Wishart, K. L. Jones, M. Horowitz, and C. Feinle-Bisset Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women Am J Physiol Gastrointest Liver Physiol, September 1, 2009; 297(3): G602 - G610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Shimotoyodome, D. Fukuoka, J. Suzuki, Y. Fujii, T. Mizuno, S. Meguro, I. Tokimitsu, and T. Hase Coingestion of Acylglycerols Differentially Affects Glucose-Induced Insulin Secretion via Glucose-Dependent Insulinotropic Polypeptide in C57BL/6J Mice Endocrinology, May 1, 2009; 150(5): 2118 - 2126. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Chaikomin, K. L. Wu, S. Doran, K. L. Jones, A. J. P. M. Smout, W. Renooij, R. H. Holloway, J. H. Meyer, M. Horowitz, and C. K. Rayner Concurrent duodenal manometric and impedance recording to evaluate the effects of hyoscine on motility and flow events, glucose absorption, and incretin release Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G1099 - G1104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. T. Gunnarsson, M. S. Winzell, C. F. Deacon, M. O. Larsen, K. Jelic, R. D. Carr, and B. Ahren Glucose-Induced Incretin Hormone Release and Inactivation Are Differently Modulated by Oral Fat and Protein in Mice Endocrinology, July 1, 2006; 147(7): 3173 - 3180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gentilcore, R. Chaikomin, K. L. Jones, A. Russo, C. Feinle-Bisset, J. M. Wishart, C. K. Rayner, and M. Horowitz Effects of Fat on Gastric Emptying of and the Glycemic, Insulin, and Incretin Responses to a Carbohydrate Meal in Type 2 Diabetes J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2062 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Little, A. N. Pilichiewicz, A. Russo, L. Phillips, K. L. Jones, M. A. Nauck, J. Wishart, M. Horowitz, and C. Feinle-Bisset Effects of Intravenous Glucagon-Like Peptide-1 on Gastric Emptying and Intragastric Distribution in Healthy Subjects: Relationships with Postprandial Glycemic and Insulinemic Responses J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1916 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Horowitz and M A Nauck To be or not to be--an incretin or enterogastrone? Gut, February 1, 2006; 55(2): 148 - 150. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Chaikomin, S. Doran, K. L. Jones, C. Feinle-Bisset, D. O'Donovan, C. K. Rayner, and M. Horowitz Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E504 - E507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Russo, J. E. Stevens, R. Chen, D. Gentilcore, R. Burnet, M. Horowitz, and K. L. Jones Insulin-Induced Hypoglycemia Accelerates Gastric Emptying of Solids and Liquids in Long-Standing Type 1 Diabetes J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4489 - 4495. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Jones, D. O'Donovan, A. Russo, J. H. Meyer, J. E. Stevens, Y. Lei, J. Keogh, A. Tonkin, and M. Horowitz Effects of drink volume and glucose load on gastric emptying and postprandial blood pressure in healthy older subjects Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G240 - G248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. G. O'Donovan, S. Doran, C. Feinle-Bisset, K. L. Jones, J. H. Meyer, J. M. Wishart, H. A. Morris, and M. Horowitz Effect of Variations in Small Intestinal Glucose Delivery on Plasma Glucose, Insulin, and Incretin Hormones in Healthy Subjects and Type 2 Diabetes J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3431 - 3435. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pilichiewicz, D. O'Donovan, C. Feinle, Y. Lei, J. M. Wishart, L. Bryant, J. H. Meyer, M. Horowitz, and K. L. Jones Effect of Lipase Inhibition on Gastric Emptying of, and the Glycemic and Incretin Responses to, an Oil/Aqueous Drink in Type 2 Diabetes Mellitus J. Clin. Endocrinol. Metab., August 1, 2003; 88(8): 3829 - 3834. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Berry, A. Russo, J. M. Wishart, A. Tonkin, M. Horowitz, and K. L. Jones Effect of solid meal on gastric emptying of, and glycemic and cardiovascular responses to, liquid glucose in older subjects Am J Physiol Gastrointest Liver Physiol, April 1, 2003; 284(4): G655 - G662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Rayner, M. Samsom, K. L. Jones, and M. Horowitz Relationships of Upper Gastrointestinal Motor and Sensory Function With Glycemic Control Diabetes Care, February 1, 2001; 24(2): 371 - 381. [Abstract] [Full Text]
|
|
|
|
 |
|
 K. Beckoff, C. G. MacIntosh, I. M. Chapman, J. M. Wishart, H. A. Morris, M. Horowitz, and K. L. Jones Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2001; 280(2): R570 - R576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. M. T. Verhagen, M. Samsom, and A. J. P. M. Smout Effects of intraduodenal glucose infusion on gastric myoelectrical activity and antropyloroduodenal motility Am J Physiol Gastrointest Liver Physiol, June 1, 1998; 274(6): G1038 - G1044. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | RSS | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
