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The Journal of Nuclear Medicine Vol. 37 No. 1 84-86
© 1996 by Society of Nuclear Medicine
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Cerebral Perfusion Imaging Evaluates Pharmacologic Treatment of Unilateral Moyamoya Disease

Masaomi Kuroki, Shigeki Nagamachi, Hiroaki Hoshi, Leo G. Flores, II, Takashi Ohnishi, Seishi Jinnouchi, Shigemi Futami and Katsushi Watanabe

Department of Radiology, Miyazaki Medical College, Miyazaki, Japan

Correspondence: For correspondence or reprints contact: Masaomi Kuroki, MD, Department of Radiology, Miyazaki Medical College, 5200 Ohaza Kihara, Kiyotake Miyazaki, Japan 889-16.

ABSTRACT

Unilateral Moyamoya disease presents as unilateral stenosis or obstruction of the supraclinoid internal carotid artery, which causes cerebral hypoperfusion resulting in seizures or TIA-like attacks. In severe cases, surgical treatment is performed with superficial temporal artery-middle cerebral artery anastomosis. In mild cases, conservative management is the treatment of choice. Flunarizine is a calcium ion anti-blocking agent, whose primary effect is that the cerebral vessels have been used for the treatment of postcerebrovascular disorders. Recently, it has been suggested that flunarizine could be used to treat Moyamoya disease. This report documents the efficacy of flunarizine to improve regional cerebral perfusion in Moyamoya disease.




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A. Kassner, X.-P. Zhu, K.-L. Li, and A. Jackson
Neoangiogenesis in Association with Moyamoya Syndrome Shown by Estimation of Relative Recirculation based on Dynamic Contrast-Enhanced MR Images
AJNR Am. J. Neuroradiol., May 1, 2003; 24(5): 810 - 818.
[Abstract] [Full Text] [PDF]


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Copyright © 1996 by the Society of Nuclear Medicine.