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Quantification of Renal Function with a Count-Based Gamma Camera Method Using Technetium-99m-MAG3 in Children

Departments of Nuclear Medicine and Urology, Hokkaido University School of Medicine, Sapporo, Japan

Correspondence: For correspondence or reprints contact: Kazuo Itoh, MD, Department of Nuclear Medicine, Hokkaido University School of Medicine, Kita-15, Nishi-7, Kita-ku, Sapporo 060, Japan.

ABSTRACT

To evaluate renal function quantitatively without blood sampling in children, renal uptake by gamma camera renography using ^99mTc-MAG3 was compared with plasma clearance by a single blood sample method as the reference. Methods: Twenty children (15 boys, 5 girls; aged 2–14 yr) with nephrourological diseases were examined prospectively in this study. The patient received an intravenous administration of 5 MBq/kg ^99mTc-MAG3 which was prepared using a commercially available kit. Gamma camera renography was performed and the renal uptake per injected dose (%RU) of the 1-min period of postinjection was calculated from a background-corrected renogram curve by computer. The plasma clearance (Clmag) of ^99mTc-MAG3 was calculated by the single blood sample method at 35 min postinjection. Results: The %RU of the 1-min period in the 1–3 min postinjection correlated well with Clmag. The best correlation was observed 1–2 min postinjection. The regression equation between total %RU (X) and Clmag (Y) (ml/min/1.73 m²) was Y = –98.509 + 20.373X (r = 0.910, s = 84.19) with standardization by BSA. The best fit regression equation between individual %RU (X) and Clmag (Y) (ml/min/1.73m²) was Y = –43.799 + 19.917X (p = 0.932, s = 43.27). Conclusion: The renal uptake method based on separate counts by gamma camera renography using ^99mTc-MAGS does not require a blood sample for quantification of renal function and may be potentially more practical in children.

Key Words: renal function • effective renal plasma flow • technetium-99m-mercaptoacetyltriglycine • pediatrics

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