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Quantitative SPECT Imaging: A Review and Recommendations by the Focus Committee of the Society of Nuclear Medicine Computer and Instrumentation Council

Department of Diagnostic Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania
Department of Radiology, Emory University, Atlanta, Georgia
Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska
Nuclear Medicine Service, Harvard Medical School and Department of Veterans Affairs Medical Center, W. Roxbury, Massachusetts
Department of Radiology and Biomedical Engineering, University of North Carolina, Chapel Hill, North Carolina
Division of Nuclear Medicine, University of Alabama, Birmingham, Alabama

Correspondence: For correspondence contact: Marc S. Rosenthal, PhD, Department of Surgery, University of Pittsburgh, Center for Biotechnology and Bioengineering, 300 Technology Dr., Pittsburgh, PA 15219.

ABSTRACT

This article is a review of the physics principles, instrumentation and reconstruction methods behind SPECT imaging. Particular attention is paid to the mechanisms that can significantly affect the accuracy of a SPECT image. We describe instrumentation advances and reconstruction methods used to correct images to improve image quality and produce quantitative images. The clinical importance of improved image quality and quantitation are also reviewed.

Key Words: single-photon emission computed tomography • quantitation • image quality

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