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The Journal of Nuclear Medicine Vol. 36 No. 8 1472-1475
© 1995 by Society of Nuclear Medicine
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SPECT Imaging of Fluorine-18

Peter K. Leichner, Hugh T. Morgan, Karen P. Holdeman, Katherine A. Harrison, Frank Valentino, Roger Lexa, Richard F. Kelly, William G. Hawkins and Glenn V. Dalrymple

Department of Radiology, University of Nebraska Medical Center, Omaha, Nebraska
Picker International, Inc., Bedford Heights, Ohio

Correspondence: For correspondence or reprints contact: Peter K. Leichner, PhD, Department of Radiology, University of Nebraska Medical Center, Omaha, NE 68198-1045.

ABSTRACT

The objective of this work was to determine the potential clinical usefulness of SPECT to image 511-keV annihilation photons. Methods: A triple-headed gamma camera equipped with ultrahigh-energy collimators was used to image 18F. Sensitivity measurements were carried out and the FWHM and FWTM were determined in air and for a unit-density scattering medium. Additionally, tomographic phantom studies were acquired to evaluate image quality. Results: The sensitivities of the three cameras were, for all practical purposes, identical. At a source-to-collimator distance of 100 mm, the FWHM and FWTM were 13 and 29 mm, respectively. A tomographic phantom study demonstrated that spheres with a diameter of 20 mm were well resolved when filled with 18F activity and placed inside a water-filled phantom. Conclusion: The triple-headed SPECT camera in this investigation is a practical means of acquiring tomographic 18F images. The reconstructed slices were of sufficient quality to be of value in some clinical studies.

Key Words: single-photon emission computed tomography • fluorine-18-FDG • collimation






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