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Myocardial Kinetics of TcN-NOET: A Neutral Lipophilic Complex Tracer of Regional Myocardial Blood Flow

Equipe de Physiopathologie Cellulaire Cardiaque et Laboratorie d'Etude des Radiopharmaceutiques, Université Joseph Fourier, Grenoble, France
CIS Bio International, Gif sur Yvette, France

Correspondence: For correspondence or reprints contact: Daniel Fagret, MD, Laboratorie d'Etude des Radiopharmaceutiques, URA CNRS 1287, Faculté de Médecine de Grenoble, 38700 La Tronche, France.

ABSTRACT

[Bis (N-etoxy, N ethyl dithiocarbamato) nitrido] ^99mTc (V) (TcN-NOET) is a new neutral lipophilic myocardial imaging agent proposed for clinical use for detecting coronary artery disease. We studied the relation between myocardial retention of TcN-NOET and myocardial blood flow (MBF) in a canine model. Methods: A wide range of MBF was induced by partial regional coronary occlusion and dipyridamole infusion (protocols 1, 2 and 3). Myocardial activity of TcN-NOET was determined by in vitro tissue counting at 15 or 90 min postinjection. Tracer activity was correlated with radiolabeled microspheres using linear regression analysis. Results: There was a linear correlation between myocardial TcN-NOET activity and microspheres in protocol 1 (r = 094, 15 min postinjection, protocol 2 (r = 0.94, 15 min postinjection after dipyridamole) and protocol 3 (r = 0.91 , 90 min postinjection after dipyridamole). When arterial occlusion was discontinued (protocol 4), there was no longer a close linear correlation (r = 0.26). The first-pass myocardial extraction action of TcN-NOET was 75.5% ± 4% under basal conditions and 85% ± 2% under hyperemic conditions (p < 0.01). Conclusion: Up to 90 min after injection, the relationship between TcN-NOET myocardial retention and blood flow is excellent over a wide range of flows. After reflow, TcN-NOET redistributes almost completely within 90 min.

Key Words: technetium-99m(N)-NOET • myocardial retention • myocardial blood flow • coronary artery disease

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