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Radiolabeled Somatostatin Analog Scintigraphy in Differentiated Thyroid Carcinoma

Services de Médecine Nucléaire et d'Histopathologie Institut Gustave-Roussy, Villejuif, France

Correspondence: For correspondence or reprints contact: Jean Lumbroso, MD, Service de Médecine Nucléaire, Institut Gustave-Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.

ABSTRACT

After intravenous administration of a radiolabeled somatostatin analog (octreotide), an image of the thyroid gland is frequently observed; few data are available, however, on somatostatin receptors in epithelial thyroid cells assessed in vitro and on images of differentiated thyroid carcinoma (DTC) with pentetreotide scintigraphy. Methods: In four patients with metastatic thyroid carcinoma, whole-body scintigraphy was performed 4 to 48 hr after injection of 110 MBq of ¹¹¹ In-pentetreotide. The results were compared to data obtained with other imaging modalities, including scintigraphy performed after administration of a therapeutic dose of ¹³¹I. Results: There were positive foci in distant metastases on ¹¹¹I In-pentetreotide scintigraphy. Pentetreotide scintigraphy was positive in two patients with an "insular" form of DTC, one of whom had a positive (faintly) ¹³¹I scan. of the other two patients with papillary DTC without radioiodine uptake, only one exhibited a certain degree of pentetreotide scintigraphy positivity in distant metastases. Conclusion: These results show promise for exploration of insular thyroid carcinoma and suggest that these carcinomas may possess functional differentiation features, including somatostatin receptors.

Key Words: thyroid cancer • thyroglobulin • somatostatin receptors • pentetreotide

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