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Increased Technetium-99m-HMPAO Uptake in Grade II Astrocytoma

Departments of Nuclear Medicine, Neuropathology and Epileptology, University of Bonn, Germany

Correspondence: For correspondence or reprints contact: Priv.-Doz. Dr. Frank Grünwald, Department Nuclear Medicine, University of Bonn, Sigmund Freud Str. 25, 53127 Bonn, Germany.

ABSTRACT

Most brain tumors show decreased uptake of blood flow tracers in brain SPECT imaging and in some cases meningiomas show increased uptake, mainly associated with high regional blood flow values (1–14). A reason for regionally increased tracer uptake is partial epilepsy when a tracer is injected during the ictal phase (15–17). We present a case of a histologically proven Grade II astrocytoma in the mesial part of the left temporal lobe that caused complex partial seizures. After tracer injection during a phase without signs of clinical seizure, markedly increased uptake of ^99mTc-hexamethylpropyleneamine oxime(^99mTc-HMPAO) occurred, although the tumor was partially calcified.

Key Words: epilepsy • astrocytoma • HMPAO • single-photon emission computer tomography • magnetic resonance imaging