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Radiation Dosimetry for Bolus Administration of Oxygen-15-Water

Centre de Recherches du Cyclotron, Université de Liège, Liège, Belgium

Correspondence: For correspondence or reprints contact: Claude Brihaye, PhD, Université de Liège, CRC B30, B-4000 Liège, Belgium.

ABSTRACT

We describe the development of a biokinetic model which permits an estimation of organ activities and the dosimetry of a bolus of ¹⁵O-water. The aim of this study was to estimate time-activity functions and deduce the cumulated activities in different organs so that the radiation absorbed dose values can be estimated. Methods: The model we used includes the right heart chambers, lungs, left heart chambers, brain, liver, kidneys, muscles, gastrointestinal tract and the remainder of the body. Activity in an organ will decay by physical decay with the decay constant, , and can diffuse in the organ. An exception is the heart, where blood is ejected from the heart chambers. Depending on the location of the organ in relation to the blood sampling point, organ activities can be calculated by convolution or deconvolution. Results: The radiation absorbed dose values were estimated and an effective dose equivalent H_E of 1.16 µSv/MBq (4.32 mrem/mCi) as well as an effective dose E of 1.15 µSv/MBq (4.25 mrem/mCi) were calculated. The cumulated activities in select organs measured by PET gave good agreement with the values calculated by this model. Conclusion: The values of effective dose equivalent and effective dose for bolus administration of ¹⁵O-water calculated from the absorbed doses estimated by the proposed kinetic model are almost three times higher than those previously published. A total of 8700 MBq (235 mCi) of ¹⁵O-water can be administered if an effective dose of 10 mSv (1 rem) is accepted.

Key Words: dosimetry • biokinetic model • oxygen-15-water • effective dose equivalent