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Dopamine-Producing Paraganglioma Not Visualized by Iodine-123-MIBG Scintigraphy

Departments of Internal Medicine I, Pulmonology, Thoracic Surgery, Nuclear Medicine and Pathology, University Hospital Rotterdam, Rotterdam, The Netherlands

Correspondence: For correspondence or reprints contact: T. van Gelder, MD, Department of Internal Medicine I, University Hospital, Rotterdam, Dr. Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.

ABSTRACT

A patient with an aorticopulmonary paraganglioma was found to have normal plasma norepinephrine and epinephrine levels and elevated dopamine levels. Iodine-123-MIBG scintigraphy did not visualize this tumor. The same finding on a negative MIBG scan in two patients with exclusively dopamine-secreting chemodectomas has been previously reported. In our patient [¹¹¹In-DTPA-D-Phe1]-octreotide scintigraphy proved to be an effective imaging technique.

Key Words: dopamine • iodine-123-MIBG scintigraphy • paraganglioma • chemodectoma