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Evaluation of Regional Cerebral Blood Flow in Massive Intracerebral Calcifications

Division of Nuclear Medicine, Department of Radiology, Medical College of Wisconsin, Milwaukee, Wisconsin

Correspondence: For correspondence or reprints contact: Yu Liu, MD, Division of Nuclear Medicine, Department of Radiology, Medical Colege of Wisconsin, PO Box 104, 8700 W. Wisconsin Ave., Milwaukee, WI 53226.

ABSTRACT

Fahr's disease is histopathologically characterized by massive bilateral calcifications of the cerebral basal ganglia, the dentate nuclei of the cerebellum and both the cerebral and cerebellar cortices. We report a case of Fahr's disease in which a ^99mTc-hexamethyl-propylenamine oxime (^99mTc-HMPAO) brain SPECT study was used to evaluate regional cerebral blood flow to the calcified regions. There was markedly decreased perfusion to the basal ganglia bilaterally as well as decreased perfusion to the cerebral cortices that correlated well with the patient's clinical condition.

Key Words: Fahr's disease • technetium-99m-HMPAO • single-photon emission computed tomography

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