HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bénard, F. Articles by Bisson, G. Search for Related Content PubMed PubMed Citation Articles by Bénard, F. Articles by Bisson, G.

Rapid Washout of Technetium-99m-MIBI from a Large Parathyroid Adenoma

Department of Nuclear Medicine and Radiation Biology, Department of Anatomy and Cell Biology and Department of Medicine, Université de Sherbrooke, Sherbrooke, Québec, Canada

Correspondence: For correspondence or reprints contact: Dr. Bernard Lefebvre, Nuclear Medicine Service, Centre Hospitalier Universitaire de Sherbrooke, 3001 12th Ave N, Sherbrooke, Québec, Canada J1H 5N4.

ABSTRACT

We report a case of rapid ^99mTc-methoxyisobutylisonitrile (MIBI) clearance from a parathyroid adenoma. A double-phase ^99mTc-MIBI parathyroid scintigraphy was performed on a 62-yr-old female evaluated for primary hyperparathyroidism. A large parathyroid adenoma was visualized caudal to the left lobe of the thyroid gland with an unusually rapid washout of the tracer from tumor tissue. Histologic tissue examination confirmed the presence of a parathyroid adenoma and the absence of oxyphil cells. Care should be taken in interpretation of ^99mTc-MIBI parathyroid scintigrams because some adenomas can present a rapid release of the radiotracer in a double-phase study. Technetium-99m-MIBI retention could be related to the number of mitochondria-rich cells in parathyroid adenomas or to hyperplasia.

Key Words: technetium-99m-MIBI • primary hyperparathyroidism

This article has been cited by other articles:

				N. Y. Mehta, J. M. Ruda, S. Kapadia, P. J. Boyer, C. S. Hollenbeak, and B. C. Stack Jr Relationship of Technetium Tc 99m Sestamibi Scans to Histopathological Features of Hyperfunctioning Parathyroid Tissue Arch Otolaryngol Head Neck Surg, June 1, 2005; 131(6): 493 - 498. [Abstract] [Full Text] [PDF]

				G. Mariani, S. A. Gulec, D. Rubello, G. Boni, M. Puccini, M. R. Pelizzo, G. Manca, D. Casara, G. Sotti, P. Erba, et al. Preoperative Localization and Radioguided Parathyroid Surgery J. Nucl. Med., September 1, 2003; 44(9): 1443 - 1458. [Abstract] [Full Text] [PDF]

				B. D. Nguyen Parathyroid Imaging with Tc-99m Sestamibi Planar and SPECT Scintigraphy RadioGraphics, May 1, 1999; 19(3): 601 - 614. [Abstract] [Full Text] [PDF]