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Department of Oral and Maxillofacial Surgery, National Research PET Center
Departments of Diagnostic Radiology, Pathology and Surgical Oncology, University Hospital Groningen, Oostersingel, Groningen, The Netherlands
Correspondence: For correspondence or reprints contact: J.W. Braams, Department of Oral and Maxillofacial Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.
ABSTRACT
The uptake of 2-deoxy-2-[18F]fluoro-D-glucose (FDG) in neck lymph nodes of twelve patients with a squamous-cell carcinoma of the oral cavity was studied with PET in order to detect and locate lymphogenic metastases. Methods: The results of FDG-PET imaging were compared with clinical, MRI and histopathologic findings. Standardized uptake values (SUV) were also calculated. Results: A sensitivity of 91% and a specificity of 88% were calculated for FDG-PET. In contrast, a sensitivity of 36% and a specificity of 94% were calculated for MRI. Calculated SUVs for reactive lymph nodes, metastatic lymph nodes and the primary tumor were undifferentiated. Conclusion: Using FDG-PET, lymph node metastases of squamous-cell carcinomas of the oral cavity can be visualized with a high sensitivity and specificity. FDG-PET can be an improvement in the evaluation of the neck.
Key Words: PET • fluorodeoxyglucose • MRI • head and neck metastases
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