HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cuocolo, A. Articles by Salvatore, M. Search for Related Content PubMed PubMed Citation Articles by Cuocolo, A. Articles by Salvatore, M.

Impaired Left Ventricular Diastolic Filling in Patients with Acromegaly: Assessment with Radionuclide Angiography

Departments of Nuclear Medicine and Internal Medicine, Universitá Federico II, National Cancer Institute, Napoli, Italy

Correspondence: For correspondence or reprints contact: Alberto Cuocolo, MD, Via Posillipo 66, 80123 Napoli, Italy.

ABSTRACT

Acromegaly is associated with increased cardiac morbidity and mortality, but it is not clear whether this is the result of a specific disease of heart muscle or of increased incidence of hypertension. Methods: Twenty-six patients with acromegaly (11 male and 15 female, mean age 45 ± 13 yr) and 15 and 12 age- and sex-matched normal controls underwent high temporal resolution radionuclide angiography and two-dimensional echocardiography at rest. Results: Normal controls and patients with acromegaly did not differ with respect to heart rate, ejection fraction, time to end systole, peak ejection rate (PER) and time to PER. In contrast, peak filling rate (PFR), normalized to end diastolic volume (EDV), or stroke volume (SV), or expressed as the ratio of PFR-to-PER was reduced (p < 0.01), time to PFR (TPFR) was prolonged (p < 0.01), and echocardiographic left ventricular mass index was higher (p < 0.001) in patients with acromegaly compared to normals. Patients with acromegaly were divided in normotensives (group 1, n = 17) and hypertensives (group 2, n = 9). Although left ventricular mass index was significantly (p < 0.01) higher in group 2 compared to group 1, PFR and time to PFR were not different between the two groups of acromegalic patients. In the entire group of patients with acromegaly significant relationships between left ventricular mass index and EDV/s (r = –0.56, p < 0.01), SV/s (r = –0.73, p < 0.001), and PFR/PER (r = –0.61, p < 0.001) were observed. Conclusion: Patients with acromegaly have impaired left ventricular diastolic filling at rest related to greater left ventricular mass index even in the absence of systemic hypertension.

Key Words: acromegaly • left ventricular • diastolic filling • radionuclide angiography

This article has been cited by other articles:

				A. Colao, A. Cuocolo, P. Marzullo, E. Nicolai, D. Ferone, A. M. Della Morte, R. Pivonello, M. Salvatore, and G. Lombardi Is the Acromegalic Cardiomyopathy Reversible? Effect of 5-Year Normalization of Growth Hormone and Insulin-Like Growth Factor I Levels on Cardiac Performance J. Clin. Endocrinol. Metab., April 1, 2001; 86(4): 1551 - 1557. [Abstract] [Full Text]

				P. L. Jager, W. Vaalburg, J. Pruim, E. G.E. de Vries, K.-J. Langen, and D. A. Piers Radiolabeled Amino Acids: Basic Aspects and Clinical Applications in Oncology J. Nucl. Med., March 1, 2001; 42(3): 432 - 445. [Abstract] [Full Text]

				A. Colao, A. Cuocolo, P. Marzullo, E. Nicolai, D. Ferone, A. M. D. Morte, M. Petretta, M. Salvatore, and G. Lombardi Impact of Patient's Age and Disease Duration on Cardiac Performance in Acromegaly: A Radionuclide Angiography Study J. Clin. Endocrinol. Metab., May 1, 1999; 84(5): 1518 - 1523. [Abstract] [Full Text]

				R. Baldelli, E. Ferretti, M.-L. Jaffrain-Rea, G. Iacobellis, G. Minniti, B. Caracciolo, C. Moroni, R. Cassone, A. Gulino, and G. Tamburrano Cardiac Effects of Slow-Release Lanreotide, a Slow-Release Somatostatin Analog, in Acromegalic Patients J. Clin. Endocrinol. Metab., February 1, 1999; 84(2): 527 - 532. [Abstract] [Full Text]

				A. Colao, A. Cuocolo, P. Marzullo, E. Nicolai, D. Ferone, L. Florimonte, M. Salvatore, and G. Lombardi Effects of 1-Year Treatment with Octreotide on Cardiac Performance in Patients with Acromegaly J. Clin. Endocrinol. Metab., January 1, 1999; 84(1): 17 - 23. [Abstract] [Full Text]

				R. Lopez-Velasco, H. F. Escobar-Morreale, B. Vega, E. Villa, J. M. Sancho, J. L. Moya-Mur, and R. Garcia-Robles Cardiac Involvement in Acromegaly: Specific Myocardiopathy or Consequence of Systemic Hypertension? J. Clin. Endocrinol. Metab., April 1, 1997; 82(4): 1047 - 1053. [Abstract] [Full Text] [PDF]