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Presurgical Diagnosis of a Primary Carcinoid Tumor of the Thymus with MIBG

Departments of Nuclear Medicine, Internal Medicine and Pathology, Gunma University School of Medicine, Gunma, Japan

Correspondence: For correspondence reprints or contact: Tsuneo Hirano, MD, Department of Nuclear Medicine, Gunma University School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma 00371, Japan.

ABSTRACT

A primary carcinoid tumor of the thymus showing ectopic ACTH syndrome was evaluated scintigraphically with four radiopharmaceuticals and a fluorescence method. Iodine-123-MIBG and ²⁰¹TI-CI scintigraphy clearly demonstrated the tumor. Gallium 67-citrate and ^99m(V)-DMSA showed no tumor uptake. The fluorescence method confirmed numerous storage granules of norepinephrine. Iodine-123-MIBG scintigraphy could be useful in the presurgical diagnosis of carcinoid tumors of the thymus.

Key Words: carcinoid • thymus • iodine-123-MIBG • thallium-201-chloride

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