HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ishibashi, M. Articles by Hayabuchi, N. Search for Related Content PubMed PubMed Citation Articles by Ishibashi, M. Articles by Hayabuchi, N.

Thallium-201 in Brain Tumors: Relationship between Tumor Cell Activity in Astrocytic Tumor and Proliferating Cell Nuclear Antigen

Divisions of Nuclear Medicine and Nuclear Medical Technology, Department of Radiology and Department of Neurosurgery, Radioisotope Institute for Basic and Clinical Medicine, Kurume University School of Medicine, Fukuoka, Japan

Correspondence: For correspondence or reprints contact: Masatoshi Ishibashi, MD, Division of Nuclear Medicine, Department of Radiology, Kurume University School of Medicine, 67 Asahi-Machi, Kurume-City. Fukuoka, 830, Japan.

ABSTRACT

This study was performed to assess the relationship between ²⁰¹TI chloride uptake and brain tumor proliferation using monoclonal antibody Ki-67 and proliferating cell nuclear antigen (PCNA). Methods: Thirty-four patients with brain tumors were studied. Serial SPECT images were recorded and thallium uptake (TI index) and washout rates in the tumors were calculated. Imaging results were compared with those from biopsy and histology. Cell proliferation was determined by PCNA or Ki-67 monoclonal antibody staining. Results: Thallium-201-chloride indices of the astrocytoma were 1.73 ± 0.17 and 1.48 ± 0.07 on early and delayed images, respectively. On the other hand, ²⁰¹TI indices for anaplastic astrocytoma were 2.60 ± 1.05 and 1.76 ± 0.93 and 3.26 ± 1.63 and 2.23 ± 0.56 for glioblastoma. The correlation coefficient between ²⁰¹TI and PCNA indices was 0.68 for astrocytic tumors. There was no Statistically significant correlation between the ²⁰¹TI (delay) and Ki-67 indices for astrocytic tumor. There were no significant differences between Ki-67/PCNA indices and washout rates. Conclusion: There was a positive correlation between PCNA but not the Ki-67 labeling index and the ²⁰¹TI index. With the use of a noninvasive technique, ²⁰¹TI index supports the PCNA index.

Key Words: thallium-201 • astrocytoma • anaplastic astrocytoma • glioblastomar

This article has been cited by other articles:

				S. Hemm, V. Rigau, J. Chevalier, M. C. Picot, L. Bauchet, H. El Fertit, M.-A. Rodriguez, L. Cif, N. Vayssiere, M. Zanca, et al. Stereotactic Coregistration of 201Tl SPECT and MRI Applied to Brain Tumor Biopsies J. Nucl. Med., July 1, 2005; 46(7): 1151 - 1157. [Abstract] [Full Text] [PDF]

				C. Walker, D. G. du Plessis, D. Fildes, B. Haylock, D. Husband, M. D. Jenkinson, K. A. Joyce, J. Broome, K. Kopitski, J. Prosser, et al. Correlation of Molecular Genetics with Molecular and Morphological Imaging in Gliomas with an Oligodendroglial Component Clin. Cancer Res., November 1, 2004; 10(21): 7182 - 7191. [Abstract] [Full Text] [PDF]

				Y.-H. Yu, W.-H. Hsu, N.-Y. Hsu, T.-Y. Lin, T.-C. Hsia, S.-S. Sun, and C.-H. Kao The Use of Dual Phase 201Tl SPECT for Differentiating Pulmonary Malignancies from Benign Lesions Jpn. J. Clin. Oncol., August 1, 2004; 34(8): 445 - 451. [Abstract] [Full Text] [PDF]

				T. Hayashi, T. Kumabe, H. Jokura, K. Fujihara, Y. Shiga, M. Watanabe, S.-i. Higano, and R. Shirane Inflammatory Demyelinating Disease Mimicking Malignant Glioma J. Nucl. Med., April 1, 2003; 44(4): 565 - 569. [Abstract] [Full Text] [PDF]

				T. Nakano, K. Asano, M. Tanaka, T. Takahashi, H. Miura, and S. Suzuki Use of 201Tl SPECT for Evaluation of Biologic Behavior in Pituitary Adenomas J. Nucl. Med., April 1, 2001; 42(4): 575 - 578. [Abstract] [Full Text]