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Functional Brain Imaging in HIV-1-Infected Children Born to Seropositive Mothers

Service Hospitalier Frédéric Joliot, CEA and INSERM U29, Orsay, France
Pediatric Neurology Service and INSERM U56, Bicêtre Hospital, Le Kremlin, Bicêtre, France
Immunohematology Unit, Children's Hospital, Paris, France

Correspondence: For correspondence or reprints contact: Catherine Chiron, MD, Service Hospitalier Frédéric Joliot, 4, Place du Général Leclerc, 91406 Orsay, France.

ABSTRACT

The aim of this work was to study cerebral function in vertically infected children with human immunodeficiency virus 1 (HIV-1). Methods: PET with ¹⁸F-labeled fluorodeoxyglucose (FDG) was performed in eight children (2.5–5.5 yr): three with severe neurological symptoms and five without. Quantitative analysis was based on gray matter cortical and subcortical regions of interest for which glucose utilization was measured. Results: Diffuse hypometabolism and subcortical hypermetabolism were found in the three children with severe neurological signs; the five other children had temporo-occipital cortical hypometabolism, mainly on the right side. Conclusion: Functional cerebral abnormalities seem to precede clinical symptoms in HIV-1 infection of the brain in children.

Key Words: human immunodeficiency virus • brain • positron emission tomography • pediatrics