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Scintigraphic Recording of Blood Volume Shifts

Center of Clinical Physiology and Hypertension, Institute of Clinical General Medicine, and Medical Therapy, University of Milan; Milan, Italy
Department of Energy, Nuclear Polytechnic, Milano, Italy
Medicina d'Urgenza and Chirurgia Vascolare, Fatebenefratelli Hospital, Milano, Italy

Correspondence: For correspondence or reprints contact: Giorgio Baccelli, MD, Institute of Clinical Physiology and Hypertension, Polyclinic of Milan, Via F.Sforza 35, 20122 Milano, Italy.

ABSTRACT

A scintigraphic device consisting of small scintillation probes tightly fixed to the skin was developed to record intravascular blood volume shifts continuously and simultaneously at several sites. The aim of the present study was to ascertain the reliability of the measurements obtained, show the blood shifts induced by common daily activities in healthy subjects and clarify the mechanisms responsible for hemodynamic changes. Methods: Measurements were made in three fields of the right lung, the liver, thighs and calves of 16 men during Valsalva maneuver, hyperventilation, various posture changes and treadmill walking. Some tests were repeated. Results: The measured blood volume shifts were always in the expected direction and in accordance with those reported in the literature; they also were reproducible. Therefore, the measurements were reliable. A pattern of blood volume changes peculiar to some common daily activities was recorded in subjects moving freely. In sights were obtained on the mechanisms responsible for the blood volume shifts. Conclusion: Our noninvasive technique provides reliable continuous measurements of blood volume changes at several sites during common daily activities and could be applied not only in healthy subjects but also in patients.

Key Words: blood shifts • lung • liver • lower limbs • equilibrium blood-pool scintigraphy

This article has been cited by other articles:

				G. Baccelli, P. Reggiani, A. Mattioli, E. Corbellini, S. Garducci, M. Catalano, S. Omboni, and G. Baccelli Hemodynamic Changes in the Lower Limbs During Treadmill Walking in Normal Subjects and in Patients with Arteriosclerosis Obliterans Angiology, September 1, 1997; 48(9): 795 - 803. [Abstract] [PDF]