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Effect of Caffeine on Myocardial Blood Flow at Rest and During Pharmacological Vasodilation

Division of Nuclear Medicine, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California
Laboratory of Structural Biology and Molecular Medicine, University of California, Los Angeles, California

Correspondence: For correspondence or reprints contact: Johannes Czernin, MD, Department of Molecular and Medical Pharmacology, UCLA School of Medicine, Los Angeles, California 90095-1735.

ABSTRACT

Stress testing with intravenous injection of dipyridamole is frequently used for noninvasive detection of coronary artery disease (CAD) with PET or SPECT. Dietary intake of caffeinated food, beverages or medication might alter both resting and dipyridamole-induced hyperemic blood flow, thereby compromising the diagnostic sensitivity of dipyridamole stress testing. Methods: To quantify the effect on myocardial blood flow at rest and during intravenous injection of dipyridamole, 12 healthy volunteers (mean age 27 ± 6 yr) with low risk for CAD were studied with dynamic PET and a tracer kinetic model for ¹³N-ammonia after 24 hr of caffeine abstinence and after caffeine intake. Results: Caffeine tended to increase the rate pressure product from 6873 ± 1494 to 7566 ± 1102 (p = 0.051), whereas resting myocardial blood flow remained unchanged (0.61 ± 0.13 versus 0.58 ± 0.07 ml/g/min, p = ns). The heart rate response to dipyridamole was inversely related to serum caffeine levels. Hyperemic blood flow (2.01 ± 0.46 versus 1.31 ± 0.0.38 ml/g/min; p < 0.001) and flow reserve (3.4 ± 0.8 versus 2.3 ± 0.7; p < 0.001) were inversely related to the caffeine dose. Coronary vascular resistance at rest tended to increase (132 ± 32 versus 147 ± 25 mmHg/ml/g/min; p = 0.06), whereas minimal coronary vascular resistance was significantly higher after caffeine (41 ± 9 to 69 ± 25mmHg/ml/g/min; p < 0.01). Conclusion: Caffeine intake alters the coronary vasomotor tone at rest, which might lower the threshold for ischemic eventsin patients with CAD. It reduces hyperemic blood flow and flow reserve and the dipyridamole-induced increase in heart rate in a dose-dependent fashion. These findings emphasize the importance of carefully screening patients for intake of caffeinated food, beverages or medication prior to dipyridamole stress testing.

Key Words: positron emission tomography • myocardial blood flow • caffeine • dipyridamole

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