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The Journal of Nuclear Medicine Vol. 35 No. 9 1488-1490
© 1994 by Society of Nuclear Medicine
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Early Detection of Post-Transplant Pancreatic Graft Dysfunction with Technetium-99m-HMPAO Scintigraphy

Lieuwe G. van der Hem, Cees J. van der Linden, Clemens H.J.M. Ticheler, Andries J. Hoitsma and Frans H.M. Corstens

Department of Surgery, Nuclear Medicine and Nephrology, University Hospital St. Radboud, Nijmegen, The Netherlands

Correspondence: For correspondence or reprints contact: LG. van der Hem, MD, Department of Surgery, University Hospital Groningen, PO Box 30.001,9700 RB Groningen, The Netherlands.

ABSTRACT

We present two cases of compromised pancreatic graft perfusion on a routine 99mTc-HMPAO-scan. The radiopharmaceutical, hexamethylpropyleneamine oxime (HMPAO), labeled with 99mTc-provided high-quality scintigraphic images of transplanted pancreatic grafts. Findings were compared with subsequently performed x-ray digital subtraction angiographs. Pathological examination of both resected grafts revealed venous thrombosis in one case and graft pancreatitis in the other case of disturbed graft perfusion on a 99mTc-HMPAO-scan. While 99mTc-HMPAO scans of pancreatic grafts are not specific for early thrombosis, they seem to be a helpful tool in diagnosing pancreatic dysfunction in general, necessitating further diagnostic steps to elucidate the specific cause.

Key Words: pancreas transplantation • technetium-99m-HMPAO scintigraphy • early graft dysfunction




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K. D. Hagspiel, K. Nandalur, T. L. Pruett, D. A. Leung, J. F. Angle, D. J. Spinosa, A. H. Matsumoto, H. Ahmed, H. A. Sanfey, R. G. Sawyer, et al.
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[Abstract] [Full Text] [PDF]




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Copyright © 1994 by the Society of Nuclear Medicine.