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Disseminated Bone Marrow Metastases from Primary Breast Cancer: Detection and Follow-up by Radioimmune Bone Marrow Scintigraphy

Departments of Nuclear Medicine, Radiology and Gynecology, University of Bonn, Bonn, Germany

Correspondence: For correspondence or reprints contact: Olaf Rieker, MD, Clinic for Nuclear Medicine, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany.

ABSTRACT

Bone scintigraphy of a 40-yr-old patient suffering from primary breast cancer suggested the possibility of diffuse metastases. Bone marrow scintigraphy using ^99mTc-labeled monoclonal antibodies (BW 250/183) demonstrated diffuse destruction of bone marrow due to metastatic disease and consecutive bone marrow extension. Bone marrow scintigraphy was highly sensitive in detecting progression of disease in this asymptomatic patient.

Key Words: bone marrow scintigraphy • repeat immunoscans • disseminated metastases • follow-up