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Schwannoma of the Extremities: Comparison of MRI and Pentavalent Technetium-99m-Dimercaptosuccinic Acid and Gallium-67-Citrate Scintigraphy

Departments of Radiology and Nuclear Medicine, and Orthopaedic Surgery, Kyoto University, Faculty of Medicine, Kyoto
Department of Nuclear Medicine, Gunma University School of Medicine, Maebashi, Japan

Correspondence: For correspondence or reprints contact: Hisataka Kobayashi, MD, Department of Radiology and Nuclear Medicine, Kyoto University, Faculty of Medicine, 54, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-01, Japan.

ABSTRACT

The diagnostic value of MRI and scintigraphy was studied in patients with Schwannomas of the upper or lower extremities. MRI (T1- and T2-weighted imaging), pentavalent ^99mTc-dimercaptosuccinic acid and ⁶⁷Ga-citrate scintigraphy were performed in 11 patients with 12 histologically proven benign Schwannomas. All six tumors with a maximum diameter 3 cm showed marked accumulation of pentavalent ^99mTc-dimercaptosuccinic acid, whereas they showed no uptake of ⁶⁷Ga-citrate. MRI detected all of the tumors, and the lesions had a signal intensity equal to or slightly less than that of skeletal muscle on T1-weighted images and hyperintense to that of subcutaneous fat on T2-weighted images. MRI was superior to detect small Schwannomas of the extremities. A positive ^99mTc-dimercaptosuccinic acid scan and a negative ⁶⁷Ga-citrate scan however is useful to distinguish sarcoma with myxoid change from Schwannoma.

Key Words: Schwannoma • pentavalent technetium-99m-dimercaptosuccinic acid • gallium-67-citrate • MRI

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