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Technetium-99m-MDP Uptake in Thyroid Cartilage in Invasive Squamous-Cell Laryngeal Carcinoma

Department of Nuclear Medicine, San Francisco General Hospital, Department of Laboratory Medicine, University of California San Francisco, San Francisco, California

Correspondence: For correspondence or reprints contact: Fabio Almeida, MD, Chief Resident, Department of Nuclear Medicine, SFGH, Building 100, Room 157, 1001 Potrero Avenue, San Francisco, CA 94110.

ABSTRACT

A 36-yr-old male with a past history of invasive squamous-cell carcinoma of the larynx underwent ^99mTc-MDP scintigraphy for the evaluation of lower back pain. The scan findings were unremarkable except for markedly and uniformly increased tracer uptake in the region of the thyroid cartilage, suggesting calcification and/or tumor invasion. Confirmation of significant pathology was obtained on tissue examination from a subsequent total laryngectomy demonstrating inflammatory infiltration and perichondrial invasion of the thyroid cartilage by carcinoma.

Key Words: technetium-99m-MDP • squamous-cell carcinoma • thyroid cartilage