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The Journal of Nuclear Medicine Vol. 35 No. 7 1134-1137
© 1994 by Society of Nuclear Medicine
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Thallium-201/Technetium-99m-Phytate (Colloid) Subtraction Imaging of Hepatocellular Carcinoma

Teruhito Mochizuki, Tomoko Takechi, Kenya Murase, W. Newlon Tauxe, Harold A. Bradfield, Shuji Tanada and Ken Hamamoto

Departments of Radiology Imabari Ehime Hospital, Ehime University School of Medicine, Ehime, Japan
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Correspondence: For correspondences and reprints contact: Teruhito Mochizuki, MD, Radiology, Ehime Imabari Hospital, 4-5-5 Ishii-cho, Imabari-city, Ehime 794, Japan.

ABSTRACT

This paper evaluates the clinical usefulness of 201Tl to image hepatocellular carcinoma (HCC), using 201Tl, 99mTc-phytate (colloid) and a three-headed SPECT camera. Methods: The tumor-to-nontumor ratios (T/N) of 201Tl for different categories of HCC were generated. Tumors were emphasized by image subtraction (201Tl-99mTc-colloid). Thirty-three lesions in 16 patients (18 studies) with HCC were evaluated. There were 19 untreated nodular, five untreated diffuse, five local recurrent and four necrotic lesions after interventional therapy. Results: The mean T/N were as follows: untreated nodular 1.54 ± 0.31 (mean ± s.d.), untreated diffuse 1.28 ± 0.26, local recurrence 1.50 ± 0.29 and necrosis 0.22 ± 0.06. All the tumors (except necrotic areas) were enhanced by the image subtraction. Conclusion: Thallium-201 is useful for liver tumor imaging but 99mTc-phytate (colloid) is essential to discriminate 201Tl tumor uptake from normal liver accumulation. Image subtraction (201Tl/99mTc-colloid) is helpful in detecting HCC.

Key Words: thallium-201 • technetium-99m-phytate • SPECT • subtraction images • hepatocellular carcinoma






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Copyright © 1994 by the Society of Nuclear Medicine.