| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Turku Cyclotron-PET Center and Departments of Clinical Physiology, Medicine and Nuclear Medicine, Turku University, Turku
Second Department of Medicine, Helsinki University, Helsinki, Finland
Correspondence: For correspondence or reprints contact: Dr. Juhani Knuuti, Department of Nuclear Medicine, Turku University Central Hospital, SF-20520 Turku, Finland.
ABSTRACT
Recently, the euglycemic hyperinsulinemic clamp technique was shown to give excellent image quality during metabolic steady-state conditions. Acipimox is a new potent nicotinic acid derivative that rapidly reduces serum free fatty acid (FFA) levels by inhibiting lipolysis in peripheral tissue. Methods: To compare the effects of acipimox administration and insulin clamp on [18F]fluorodeoxyglucose([18F]FDG) uptake and myocardial glucose utilization, five nondiabetic and seven type II diabetic patients who had had previous myocardial infarctions were studied twice: once during a clamp study and once after the administration of acipimox (2 x 250 mg orally). All patients also underwent resting SPECT perfusion imaging prior to PET scans. Results: The patients tolerated acipimox well. Although fasting plasma glucose levels were higher in diabetic patients (9.2 ± 3.4 versus 5.5 ± 0.3 mM, p = 0.03), they were decreased both during clamping and after acipimox; during imaging, no significant differences between the groups and approaches were detected. By visual analysis, the image quality and myocardial [18F]FDG uptake patterns were similar during clamping and after acipimox. Compared with the relative [18F]FDG uptake values obtained during clamping, acipimox yielded similar results in normal, mismatch and scar segments (r = 0.88, p = 0.0001). Similar rMGU values were also obtained during both approaches. Conclusion: Thus, PET imaging with [18F]FDG after the administration of acipimox is a simple and feasible method for clinical viability studies both in nondiabetic and diabetic patients. It results in excellent image quality and gives rMGU levels similar to the insulin clamp technique.
Key Words: myocardial glucose metabolism • PET • glucose-insulin clamp • acipimox • coronary artery disease
This article has been cited by other articles:
|
|
 |
|
  H. Tuunanen, A. Naum, K. Nagren, P. Nuutila, P. Iozzo, H. Ukkonen, J. Knuuti, E. Engblom, K.E. J. Airaksinen, B. Hesse, et al. Response to Letters Regarding Article, "Free Fatty Acid Depletion Acutely Decreases Cardiac Work and Efficiency in Cardiomyopathic Heart Failure" Circulation, May 29, 2007; 115(21): e547 - e547. [Full Text] [PDF]
|
|
|
|
 |
|
 R. H.J.A. Slart, A. Agool, D. J. van Veldhuisen, R. A. Dierckx, and J. J. Bax Nitrate Administration Increases Blood Flow in Dysfunctional but Viable Myocardium, Leading to Improved Assessment of Myocardial Viability: A PET Study J. Nucl. Med., August 1, 2006; 47(8): 1307 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. Kuhl, C. S.A. Lipke, G. A. Krombach, M. Katoh, T. F. Battenberg, B. Nowak, N. Heussen, A. Buecker, and W. M. Schaefer Assessment of reversible myocardial dysfunction in chronic ischaemic heart disease: comparison of contrast-enhanced cardiovascular magnetic resonance and a combined positron emission tomography-single photon emission computed tomography imaging protocol Eur. Heart J., April 1, 2006; 27(7): 846 - 853. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F.L. Schinkel, D. Poldermans, V. Rizzello, R. T. van Domburg, R. Valkema, A. Elhendy, E. Biagini, E. P. Krenning, M. L. Simoons, and J. J. Bax Impact of Diabetes Mellitus on Prediction of Clinical Outcome After Coronary Revascularization by 18F-FDG SPECT in Patients with Ischemic Left Ventricular Dysfunction J. Nucl. Med., January 1, 2006; 47(1): 68 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk Myocardial Substrate Metabolism in the Normal and Failing Heart Physiol Rev, July 1, 2005; 85(3): 1093 - 1129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Bax, A. F.L. Schinkel, E. Boersma, A. Elhendy, V. Rizzello, A. Maat, J. R.T.C. Roelandt, E. E. van der Wall, and D. Poldermans Extensive Left Ventricular Remodeling Does Not Allow Viable Myocardium to Improve in Left Ventricular Ejection Fraction After Revascularization and Is Associated With Worse Long-Term Prognosis Circulation, September 14, 2004; 110(11_suppl_1): II-18 - II-22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.R. Underwood, J. J Bax, J. v. Dahl, M. Y Henein, A. C van Rossum, E. R Schwarz, J.-L. Vanoverschelde, E. E.v. d. Wall, and W. Wijns Imaging techniques for the assessment of myocardial hibernation: Report of a Study Group of the European Society of Cardiology Eur. Heart J., May 2, 2004; 25(10): 815 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F.L. Schinkel, J. J. Bax, R. Valkema, A. Elhendy, R. T. van Domburg, E. C. Vourvouri, M. A. Bountioukos, E. P. Krenning, J. R.T.C. Roelandt, and D. Poldermans Effect of Diabetes Mellitus on Myocardial 18F-FDG SPECT Using Acipimox for the Assessment of Myocardial Viability J. Nucl. Med., June 1, 2003; 44(6): 877 - 883. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F.L. Schinkel, J. J. Bax, R. van Domburg, A. Elhendy, R. Valkema, E. C. Vourvouri, F. B. Sozzi, J. R.T.C. Roelandt, and D. Poldermans Dobutamine-Induced Contractile Reserve in Stunned, Hibernating, and Scarred Myocardium in Patients with Ischemic Cardiomyopathy J. Nucl. Med., February 1, 2003; 44(2): 127 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L.R. Kam, R. Valkema, D. Poldermans, J. J. Bax, A. E.M. Reijs, R. Rambaldi, E. Boersma, T. Rietveld, J. R.T.C. Roelandt, and E. P. Krenning Feasibility and Image Quality of Dual-Isotope SPECT Using 18F-FDG and 99mTc-Tetrofosmin After Acipimox Administration J. Nucl. Med., February 1, 2003; 44(2): 140 - 145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Schaefer, B. Nowak, H.-J. Kaiser, K.-C. Koch, S. Block, J. vom Dahl, and U. Buell Comparison of Microsphere-Equivalent Blood Flow (15O-Water PET) and Relative Perfusion (99mTc-Tetrofosmin SPECT) in Myocardium Showing Metabolism-Perfusion Mismatch J. Nucl. Med., January 1, 2003; 44(1): 33 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. D. Vitale, R. A. deKemp, T. D. Ruddy, K. Williams, and R. S.B. Beanlands Myocardial Glucose Utilization and Optimization of 18F-FDG PET Imaging in Patients with Non-Insulin-Dependent Diabetes Mellitus, Coronary Artery Disease, and Left Ventricular Dysfunction J. Nucl. Med., December 1, 2001; 42(12): 1730 - 1736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R Rambaldi, D Poldermans, J.J Bax, E Boersma, A Elhendy, W Vletter, J.R.T.C Roelandt, and R Valkema Doppler tissue velocity sampling improves diagnostic accuracy during dobutamine stress echocardiography for the assessment of viable myocardium in patients with severe left ventricular dysfunction Eur. Heart J., July 1, 2000; 21(13): 1091 - 1098. [Abstract] [PDF]
|
|
|
|
 |
|
 H. Schoder, R. Campisi, T. Ohtake, C. K. Hoh, D. H. Moon, J. Czernin, and H. R. Schelbert Blood flow-metabolism imaging with positron emission tomography in patients with diabetes mellitus for the assessment of reversible left ventricular contractile dysfunction J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1328 - 1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. R. Russell III, R. Yin, M. J. Caplan, X. Hu, J. Ren, G. I. Shulman, A. J. Sinusas, and L. H. Young Additive Effects of Hyperinsulinemia and Ischemia on Myocardial GLUT1 and GLUT4 Translocation In Vivo Circulation, November 17, 1998; 98(20): 2180 - 2186. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
