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Technetium-99m-N,N-Ethylenedicysteine—A Comparative Study of Renal Scintigraphy with Technetium-99m-MAG3 and Iodine-131-OIH in Patients with Obstructive Renal Disease

Kutlan Özker, çetin Önsel, Levent Kabasakal, Haluk Burçak Sayman, lhami Uslu, ükrü Bozluolçay, Tülay Cansiz, Tarik Kapiciolu and rfan Urganciolu

Department of Nuclear Medicine, Cerrahpaa Medical Faculty, Istanbul, Turkey

Correspondence: For correspondence or reprints contact: Levent Kabasakal, MD, Nükleer Tip Anabilim Dal Cerrahpaa Tip Fakültesi, Aksaray, Istanbul, Turkey.

ABSTRACT

Technetium-99m-labeled N,N-ethylenedicysteine (^99mTc-EC) is a new renal imaging agent introduced as an alternative for ^99mTc-labeled mercaptoacetyltriglycine (^99mTc-MAG3), with similar renal excretion characteristics. To evaluate the diagnostic characteristics of this agent, a gamma camera study was performed. Methods: Sixteen patients with obstructive renal disease and six normal controls were injected with 90 to 110 MBq of ^99mTc-EC and 7.4 MBq ¹³¹I-labeled orthoiodohippurate (OIH). Serial images were obtained during 20 min for ^99mTc-EC and 30 min for OIH. The study was repeated using 90 to 110 MBq ^99mTc-MAG3 during the same week. Results: Renograms, functional ratios and urinary excretion patterns of all three agents were similar. The mean time to peak activity values for OIH, ^99mTc-EC and ^99mTc-MAG3 were 4.25 ± 0.37 min, 4.39 ± 0.32 min and 4.00 ± 0.24 min, respectively. The time from peak to 50% activity values for OIH, ^99mTc-EC and ^99mTc-MAG3 were 5.48 ± 0.80 min, 6.93 ± 0.69 min and 7.33 ± 0.85 min, respectively. Conclusion: It is concluded that ^99mTc-EC has excellent imaging characteristics and similar excretion properties to OIH. The advantages of ^99mTc-EC over ^99mTc-MAG3 are lower hepatobiliary uptake and simplicity of preparation.

Key Words: ethylenedicysteine • MAG3 • OIH • renogram

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