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Myocardial Perfusion Imaging with Technetium-99m-Teboroxime

Division of Cardiology, University of Alabama Medical Center, Birmingham, Alabama

Correspondence: For correspondence or reprints contact: Lynne L. Johnson, MD, Division of Cardiology, THT-311, University of Alabama Medical Center, 1900 University Blvd., Birmingham, AL 35294.

ABSTRACT

Technetium-99m-teboroxime is a myocardial perfusion imaging radiotracer that, although not widely used in clinical practice, has the potential to provide valuable diagnostic information. Teboroxime's high myocardial extraction and rapid in vivo myocardial clearance make stress/rest studies possible using very short imaging protocols. In addition, differential washout of ^99mTc-teboroxime produces defect fill in on early delayed images in a high percentage of patients, potentially eliminating the need for a second rest injection. Finally, because of its rapid myocardial clearance, serial injections of ^99mTc-teboroxime in an acute myocardial infarction (MI) setting can provide information on infarct vessel patency based on defect size and can help document the success or failure of reperfusion therapy.

Key Words: myocardial perfusion imaging • technetium-99m-teboroxime

FOOTNOTES

This paper was presented in part at the Annual Meeting of the Society of Nuclear Medicine on June 8, 1993, as part of a Continuing Medical Education Seminar organized by The Cardiovascular Council.