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The Journal of Nuclear Medicine Vol. 35 No. 4 575-579
© 1994 by Society of Nuclear Medicine
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Clinical Utility of Technetium-99m-Teboroxime Myocardial Washout Imaging

Milena J. Henzlova and Josef Machac

Division of Nuclear Medicine and Cardiology, Mount Sinai Medical Center, New York, New York

Correspondence: For correspondence contact: M.J. Henzlova, MD, The Mount Sinai Medical Center, Division of Cardiology, One Gustave L. Levy Place, New York, NY 10029.

ABSTRACT

The purpose of this study was to evaluate the clinical utility of 99mTc-teboroxime myocardial washout imaging. The differential washout after a single tracer injection has been proposed as an alternative for characterization of the perfusion defects. Methods: Fifty-six patients received 5-min adenosine infusion. The stress dose of 99mTc-taboroxime was injected at 4.5 min and stress imaging with a single-headed SPECT gamma camera was started at 6 min, washout imaging followed immediately. At 20 min, the rest tracer dose was injected at rest and imaging was started at 21.5 min. The reversibility of the perfusion defects on the washout and rest images was compared visually and quantitatively. Results: There was no statistical difference in the number of stress defects that improved on the washout and rest images. The visual interpretation of the perfusion abnormalities was confirmed by quantitative analysis of relative segmental activity. Conclusion: Thus, 99mTc-teboroxime-adenosine washout myocardial perfusion imaging can be safely and quickly accomplished. Detected reversibility of the perfusion defects did not significantly differ from reversibility observed on the rest images.

Key Words: technetium-99m-teboroxime • washout imaging • adenosine stress







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Copyright © 1994 by the Society of Nuclear Medicine.