| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri
Correspondence: For correspondence or reprints contact: Pilar Herrero, MS, Cardiovascular Division, Washington University School of Medicine, Box 8086, 660 S. Euclid Ave., St. Louis, MO 63110.
ABSTRACT
Estimates of myocardial perfusion with PET using kinetic models require faithful recording of radioactivity content in blood and myocardium. Typically the arterial time-activity curve is obtained by placing a region of interest (ROIs) within the left atrial or left ventricular cavity. However, curves generated from these regions appear earlier in time than tissue time-activity curves obtained from ROIs within the myocardial tissue, and such time discrepancies can lead to errors in flow estimates. Methods: The magnitude of these time discrepancies and their effect on estimates of regional myocardial perfusion using oxygen-15-water were measured in 30 normal subjects evaluated at rest and again after administration of dipyridamole. Results: Under baseline conditions, the left atrial curve appeared 0.97 ± 0.67 (s.d.) before the ascending aorta input curve (p < 0.05) and estimated perfusion decreased from 1.28 ± 0.28 ml/g/min using the left atrial curve uncorrected for time to 0.98 ± 0.27 ml/g/min after correction (p < 0.05). After dipyridamole, the left atrial curve appeared 0.68 ± 0.72 sec before the ascending aorta curve (p < 0.05) and estimated perfusion decreased from 3.60 ± 1.40 ml/g/min using the left atrial curve uncorrected for time to 3.24 ± 1.26 ml/g/min using the time-corrected curve (p < 0.05). Because the magnitude of time discrepancies between the left ventricular and ascending aortic curves was less (0.25 ± 0.34 and 0.19 ± 0.23 sec at rest and after dipyridamole, respectively), effects on flow estimates were more modest. Conclusions: The results of this study demonstrate that time discrepancies between input and tissue time-activity curves can affect estimates of myocardial flow. Correction for this potential source of error is proposed.
Key Words: PET • myocardial perfusion imaging
This article has been cited by other articles:
|
|
 |
|
  P. Herrero, Z. Kisrieva-Ware, C. S. Dence, B. Patterson, A. R. Coggan, D.-H. Han, Y. Ishii, P. Eisenbeis, and R. J. Gropler PET Measurements of Myocardial Glucose Metabolism with 1-11C-Glucose and Kinetic Modeling J. Nucl. Med., June 1, 2007; 48(6): 955 - 964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Welch, J. S. Lewis, J. Kim, T. L. Sharp, C. S. Dence, R. J. Gropler, and P. Herrero Assessment of Myocardial Metabolism in Diabetic Rats Using Small-Animal PET: A Feasibility Study J. Nucl. Med., April 1, 2006; 47(4): 689 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Herrero, J. Kim, T. L. Sharp, J. A. Engelbach, J. S. Lewis, R. J. Gropler, and M. J. Welch Assessment of Myocardial Blood Flow Using 15O-Water and 1-11C-Acetate in Rats with Small-Animal PET J. Nucl. Med., March 1, 2006; 47(3): 477 - 485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Srinivasan, P. Herrero, J. B. McGill, J. Bennik, B. Heere, D. Lesniak, V. G. Davila-Roman, and R. J. Gropler The Effects of Plasma Insulin and Glucose on Myocardial Blood Flow in Patients With Type 1 Diabetes Mellitus J. Am. Coll. Cardiol., July 5, 2005; 46(1): 42 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Herrero, T. L. Sharp, C. Dence, B. M. Haraden, and R. J. Gropler Comparison of 1-11C-Glucose and 18F-FDG for Quantifying Myocardial Glucose Use with PET J. Nucl. Med., November 1, 2002; 43(11): 1530 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-C. Richard, M. Janier, F. Decailliot, D. Le Bars, F. Lavenne, V. Berthier, M. Lionnet, L. Cinotti, G. Annat, and C. Guerin Comparison of PET with Radioactive Microspheres to Assess Pulmonary Blood Flow J. Nucl. Med., August 1, 2002; 43(8): 1063 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-W. Lin, A. F. Laine, O. Akinboboye, and S. R. Bergmann Use of Wavelet Transforms in Analysis of Time-Activity Data from Cardiac PET J. Nucl. Med., February 1, 2001; 42(2): 194 - 200. [Abstract] [Full Text]
|
|
|
|
|
|
J. H. S. Cullen, M. A. Horsfield, C. R. Reek, G. R. Cherryman, D. B. Barnett, and N. J. Samani A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging J. Am. Coll. Cardiol., April 1, 1999; 33(5): 1386 - 1394. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Lee, V. G. Davila-Roman, P. A. Ludbrook, M. Courtois, J. F. Walsh, D. A. Delano, P. J. Rubin, and R. J. Gropler Dependency of Contractile Reserve on Myocardial Blood Flow : Implications for the Assessment of Myocardial Viability With Dobutamine Stress Echocardiography Circulation, November 4, 1997; 96(9): 2884 - 2891. [Abstract] [Full Text]
|
|
|
|
|
|
D. D. Miller, T. J. Donohue, T. L. Wolford, M. J. Kern, S. R. Bergmann, C. M. Mechem, and J. J. Hartman Assessment of Blood Flow Distal to Coronary Artery Stenoses: Correlations Between Myocardial Positron Emission Tomography and Poststenotic Intracoronary Doppler Flow Reserve Circulation, November 15, 1996; 94(10): 2447 - 2454. [Abstract] [Full Text]
|
|
|
|
|
|
J. vom Dahl, O. Muzik, E. R. Wolfe Jr, C. Allman, G. Hutchins, and M. Schwaiger Myocardial Rubidium-82 Tissue Kinetics Assessed by Dynamic Positron Emission Tomography as a Marker of Myocardial Cell Membrane Integrity and Viability Circulation, January 15, 1996; 93(2): 238 - 245. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| JOURNAL OF NUCLEAR MEDICINE TECHNOLOGY | THE JOURNAL OF NUCLEAR MEDICINE |
