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Kinetic Modeling of Teboroxime Using Dynamic SPECT Imaging of a Canine Model

Department of Radiology, Division of Nuclear Medicine, Medical Imaging Research Laboratory and the Bioengineering Department, University of Utah, Salt Lake City, Utah

Correspondence: For correspondence and reprints contact: Grant T. Gullberg, PhD, Director, Medical Imaging Research Laboratory, AC213 SOM MIRL, University of Utah, Salt Lake City, UT 84132.

ABSTRACT

The tomographic utility of ^99mTc-labeled teboroxime has been limited because of its fast washout from the heart, which requires rapid data acquisitions that have not been feasible until the recent development of multidetector SPECT systems. Methods: Using a three-detector SPECT system to acquire dynamic tomographic data every 10.2 sec, we investigated the potential of modeling the kinetics of teboroxime to develop a sensitive and quantitative measure of cardiac perfusion. Seven studies were performed on four dogs; in three of the studies the LAD artery was occluded. The three-dimensional activity distributions were reconstructed and were corrected for attenuation using a transmission scan. Time-activity curves from the blood and tissue were fit to a two-compartment model with two-way exchange. Results: Performing attenuation correction during the reconstruction process affected the washin parameter k₂₁ significantly (p < 0.0001). The washin parameter k₂₁ also decreased significantly (p < 0.002) when the LAD was occluded. Conclusions: The results indicate that the washin of teboroxime in myocardial tissue (k₂₁) measured using dynamic SPECT imaging and kinetic modeling is an indicator of myocardial blood flow.

Key Words: cardiac SPECT • ^99mTc-teboroxime • kinetic modeling

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