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Radioiodine Uptake by Squamous-Cell Carcinoma of the Lung

Department of Nuclear Medicine, School of Medicine and Chest Disease Research Institute, Kyoto University, Kyoto, Japan

Correspondence: For correspondence and reprint requests contact: T. Misaki, MD, Dept of Nuclear Medicine, Kyoto University School of Medicine, Shogoin, Sakyo-ku, Kyoto 606 Japan.

ABSTRACT

A patient with a history of total thyroidectomy for papillary carcinoma showed a solitary hot spot in the chest on post-therapy radioiodine imaging. Subsequent evaluation demonstrated that this lesion was a primary squamous-cell lung cancer. Our case illustrates a rare but important differential diagnosis from lung metastasis of thyroid cancer in ¹³¹I scintigraphy. Alternatively, this "aberrant uptake" might be a rather common phenomenon for lung neoplasms, although the underlying mechanism is not yet known. Future experimental studies might lead to a new application of radioiodine imaging in pulmonary oncology.

Key Words: squamous-cell carcinoma • radioiodine scintigraphy • thyroid cancer

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