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Cerebral Blood Flow in Sneddon Syndrome

Departments of Nuclear Medicine and Dermatology, University of Bonn, Bonn, Germany

Correspondence: For correspondence or reprints contact: Christian Menzel, MD, Dept. of Nuclear Medicine, University of Bonn, Sigmund Freud Str. 25, 5300 Bonn 1 Germany.

ABSTRACT

Sneddon syndrome is defined as a clinical entity consisting of livedo racemosa generalisata (LRG) and cerebrovascular lesions, which often lead to physical and mental handicaps. Four patients with LRG and the suspected diagnosis of Sneddon syndrome had HMPAO-SPECT studies. The patients underwent CT and/or MR brain imaging and three patients had Duplex sonography of the cerebral arteries (TCD). Brain SPECT was abnormal in all patients, whereas CT/MRI revealed a cerebral lesion in only one patient and all TCD studies were normal. HMPAO-SPECT is valuable in detecting disturbed region at cerebral blood flow before irreversible ischemic insults occur, thus allowing the diagnosis of Sneddon syndrome at an early stage.

Key Words: technetium-99m-HMPAO • SPECT • Sneddon syndrome • rCBF

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