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Visualization of Damaged Brain Tissue After Ischemic Stroke with Cobalt-55 Positron Emission Tomography

Departments of Biological Psychiatry, Neurology, PET-Research Center, and Departments of Neuro-Radiology and Pharmacy, University Hospital Groningen, The Netherlands

Correspondence: For correspondence and reprints contact: H.M.L. Jansen, Depts. of Biological Psychiatry and Neurology, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands.

ABSTRACT

In animal experiments, the radionuclide ⁵⁵Co²⁺ has been shown to accumulate indegenerating cerebral tissue similar to Co²⁺. Methods: The potential role of ⁵⁵Co²⁺ in vivo brain PET imaging was investigated in four patients after ischemic stroke. Results: PET showed uptake of ⁵⁵Co²⁺ in damaged brain tissue irrespective of blood-brain barrier integrity, as affirmed by CT and MRI. Conclusion: Our preliminary results indicate that ⁵⁵CoCl₂ may prove to be a useful and relatively inexpensive PET radiopharmaceutical for visualization of degenerative processes in brain tissue.

Key Words: cobalt • PET • ischemic damage • stroke