HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Charron, M. Articles by Bhargava, S. Search for Related Content PubMed PubMed Citation Articles by Charron, M. Articles by Bhargava, S.

Detection of Inflammatory Bowel Disease in Pediatric Patients with Technetium-99m-HMPAO-Labeled Leukocytes

Departments of Radiology, Gastroenterology, Children's Hospital of Pittsburgh and University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Correspondence: For correspondence or reprints contact: Martin Charron, MD, Division of Nuclear Medicine, Department of Radiology, Children's Hospital of Pittsburgh, 3705 Fifth Ave., Pittsburgh, PA 15213.

ABSTRACT

Technetium-99m-HMPAO-labaled leukocyte imaging is now an accepted technique in the assessment of adult patients with inflammatory bowel disease (IBD), but its role in pediatric patients has not been studied. Methods: We evaluated the efficacy of ^99mTc-HMPAO-labeled leukocyte imaging in 21 children. We studied 16 children with active IBO (4 ulcerative colitis, 10 Crohn's disease, 1 in determinate colitis, 1 C-difficile) and 5 controls. Results: The sensitivity and specificity for active bowel inflammation were excellent. The intensity of uptake noted in most patients rendered image interpretation easy and straight forward. The inclusion of a tail on detector (TOD) view and anterior standing view of the abdomen is important. All patients with ulcerative colitis showed rectosigmoid disease and no small bowel activity, whereas, all patients with Crohn's disease showed discontinuous uptake and often small bowel activity. It was therefore possible to differentiate ulcerative collitis from Crohn's disease on the basis of location and distribution. Conclusion: The ^99mTc-HMPAO-labeled leukocyte scan is an excellent technique for the detection, localization and characterization of IBD in children.

Key Words: pediatric • inflammatory bowel disease • ^99mTc-HMPAO leukocytes

This article has been cited by other articles:

				G. Mariani, E. K.J. Pauwels, A. AlSharif, S. Marchi, G. Boni, M. Barreca, M. Bellini, M. Grosso, N. de Bortoli, G. Mumolo, et al. Radionuclide Evaluation of the Lower Gastrointestinal Tract J. Nucl. Med., May 1, 2008; 49(5): 776 - 787. [Abstract] [Full Text] [PDF]

				K. Peacock, U. Porn, R. Howman-Giles, E. O'Loughlin, R. Uren, K. Gaskin, S. Dorney, and R. Kamath 99mTc-Stannous Colloid White Cell Scintigraphy in Childhood Inflammatory Bowel Disease J. Nucl. Med., February 1, 2004; 45(2): 261 - 265. [Abstract] [Full Text] [PDF]

				M. Charron Inflammatory Bowel Disease Activity Assessment with Biologic Markers and 99mTc-WBC Scintigraphy: Are There Different Trends in Ileitis Versus Colitis? J. Nucl. Med., October 1, 2003; 44(10): 1586 - 1591. [Abstract] [Full Text] [PDF]

				B.-F. Lee, N.-T. Chiu, D.-C. Wu, K.-B. Tsai, G.-C. Liu, H.-S. Yu, and S.-T. Wang Use of 99mTc (V) DMSA Scintigraphy in the Detection and Localization of Intestinal Inflammation: Comparison of Findings at Colonoscopy and Biopsy Radiology, August 1, 2001; 220(2): 381 - 385. [Abstract] [Full Text] [PDF]

				S M Davison, S Chapman, and M S Murphy 99mTc-HMPAO leucocyte scintigraphy fails to detect Crohn's disease in the proximal gastrointestinal tract Arch. Dis. Child., July 1, 2001; 85(1): 43 - 46. [Abstract] [Full Text] [PDF]

				M. Charron, F. J. del Rosario, and S. A. Kocoshis Pediatric Inflammatory Bowel Disease: Assessment with Scintigraphy with 99mTc White Blood Cells Radiology, August 1, 1999; 212(2): 507 - 513. [Abstract] [Full Text]