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Impaired Lung Epithelial Permeability in Diabetics Detected by Technetium-99m-DTPA Aerosol Scintigraphy

Departments of Nuclear Medicine and Endocrinology, Hacettepe University Medical Faculty
Department of Statistics, Hacettepe University, Ankara, Turkey

Correspondence: For correspondence and reprints contact: Biray Caner, MD, Dept. of Nuclear Medicine, Hacettepe University Medical School, Ankara, 06100 Turkey.

ABSTRACT

The clearance of inhaled ^99mTc-diethyl triaminepentaacetic acid (DTPA) aerosol from the lungs is used as an index of lung epithelial permeability. We investigated the involvement of the lung in diabetic patients using ^99mTc-DTPA aerosol scintigraphy. Methods: A total of 33 diabetic patients were studied. Thirteen had complications such as retinopathy and/or nephropathy (Group A) and 20 were without complications (Group B). As a control group, 20 healthy nonsmokers were studied. Dynamic scintigrams (2 min/frame, up to 30 min) were obtained following inhalation of ^99mTc-DTPA through a radioaerosol delivery system. Time-activity curves were obtained and half-time (T_1/2) of DTPA was measured from the curves. Results: The mean T_1/2 values (min ± s.d.) were calculated to be 133.05 ± 46.97, 93.67 ± 21.23, 9197 ± 1821 (Group A, Group B and controls, respectively). The mean T_1/2 of Group A was significantly longer than controls (p < 0.005) and than that of Group B (p < 0.005) indicating decreased epithelial permeability. No such statistical difference was detected between Group B and controls (p > 0.05). Conclusion: The lung is a target organ in diabetes and lung involvement is closely related to other vascular complications. The presence of lung involvement can be readily detected by ^99mTc-DTPA aerosol scintigraphy.

Key Words: technetium-99m-DTPA • lung epithelial permeability • diabetes mellitus • ^99mTc-DTPA aerosol scintigraphy

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