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Evaluation of Technetium-99m-L,L-EC in Renal Transplant Recipients: A Comparative Study with Technetium-99m-MAG3 and Iodine-125-OIH

Center of Nuclear Medicine and Division of Renal Transplantation, University of Louvain Medical School, Brussels
Laboratory of Radiopharmaceutical Chemistry F.F.W., K. U. Leuven, Leuven, Belgium

Correspondence: For correspondence or reprints contact: Dr. M. Stoffel, MD, Center of Nuclear Medicine, University of Louvain Medical School, UCL 5430, Avenue Hippocrate 54, 8-1200 Brussels, Belgium.

ABSTRACT

The clinical usefulness of kit-formulated ^99mTc-L,L-EC, a new renal tubular tracer agent based on a diaminodithiol ligand was evaluated in a large population of renal transplant recipients. Methods: Fifty patients with transplants were studied. Five patients with renal insufficiency and five normal volunteers were also included to extend the range of renal function values. The labeling efficiency of ^99mTc-L,L-EC in routine conditions, i.e., without HPLC purification, and the safety of the tracer were evaluated. Results: The mean radiochemical purity of ^99mTc-L,L-EC determined by thin-layer chromatography was 97.4%. No side effects or significant biochemical changes were observed. The clearance of ^99mTc-L,L-EC and ¹²⁵I-OIH ranged from 10.7 to 417.5 and from 27.6 to 602.7 ml/min/1.73 m², respectively. The clearance of ^99mTc-L,L-EC and ^99mTc-MAG3 averaged respectively 71% and 52% of that of ¹²⁵I-OIH. Conclusion: The labeling procedure of kit-formulated ^99mTc-L,L-EC is easy and efficient. This tracer is safe and suitable for both imaging and quantitative measurement of the renal tubular function. Technetium-99m-L,L-EC represents an excellent alternative to ^99mTc-MAG3.

Key Words: LLEC • MAG3 • ERPF • tubular tracer • kidney transplant