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Detection of Multiple Thromboembolism in Congenital Antithrombin III Deficiency with Indium-111-Platelet Scintigraphy

First Department of Medicine and Department of Radiology, Teikyo University School of Medicine, 11-1, Kaga, 2 Chome, Itabashi-ku, Tokyo 173, Japan

Correspondence: For correspondence contact: Dr. Kazuo Kawasugi, Centre for Immunology, St. Vincent's Hospital, Victoria Road, Darlinghurst, NSW, 2010 Australia.

Correspondence: For reprint requests contact: Dr. Kengo Gohchi, First Department of Medicine, Teikyo University School of Medicine, 11-1, Kaga, 2 Chome, Itabashi-Ku, Tokyo 173, Japan.

ABSTRACT

Congenital deficiency of antithrombin III (AT III), a physiological inhibitor of blood coagulation, may lead to increased thromboembolism. Here, we report a case of multiple thromboembolism associated with congenital AT III deficiency. The diagnosis of systemic thromboembolism was made by ¹¹¹In-labeled platelet scintigraphy (In-scan) which allowed for the daily assessment of thromboemboli size. Thromboemboli were found not only in sites predicted clinically, but also in unexpected sites. In these patients, thus, a careful whole-body examination is necessary for full detection of thromboemboli. In-scan may be a useful technique for such screening.

Key Words: congenital antithrombin III deficiency • multiple thromboembolism • indium-111-labeled platelet scintigraphy