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Iodine-131 in Breast Milk Following Therapy for Thyroid Carcinoma

Departments of Nuclear Medicine and Medical Physics, Royal Perth Hospital, Perth, Australia

Correspondence: For correspondence or reprints contact: Patrick S. Robinson, FRACP, Dept. of Nuclear Medicine, Royal Perth Hospital, Wellington St., Perth, Western Australia 6001.

ABSTRACT

This study evaluates breast milk secretion of ¹³¹I following therapeutic administration of 4000 MBq of ¹³¹I-iodide during lactation. Methods: Breast milk ¹³¹I activity concentration was measured over a 32-day period. Dosimetry calculations were undertaken to estimate the period for discontinuation of breast feeding and the equivalent dose to the breasts. Results: To achieve an infant effective dose <1 mSv and an infant thyroid dose <10 mSv, breast feeding would need to be discontinued for at least 52 days. The estimated equivalent dose to the breasts was 1.6 Gy. Conclusion: It is suggested that ¹³¹I-iodide administration is not undertaken during lactation and that breast feeding is discontinued several days prior to administration.

Key Words: thyroid carcinoma • iodine-131 therapy • breast milk

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