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Disseminated Intravascular Coagulation in a Patient with Metastatic Prostate Cancer: Fatal Outcome Following Strontium-89 Therapy

University of British Columbia, Division of Radiation Oncology and Department of Laboratory Medicine, British Columbia Cancer Agency
Division of Nuclear Medicine, Vancouver General Hospital, Vancouver, British Columbia, Canada

Correspondence: For correspondence and reprints contact: Carson Leong, MD, Division of Radiation Oncology, British Columbia Cancer Agency, 600 West 10th Ave., Vancouver, B.C. V5Z 4E6, Canada.

ABSTRACT

A patient with metastatic prostate cancer was found to have low-grade disseminated intravascular coagulation (DIC). He had significant bone pain despite external-beam radiotherapy and was given ⁸⁹Sr with subsequent thrombocytopenia and epistaxis. The patient died from generalized hemorrhage 36 days postinjection. Although it is not possible to establish a causal relationship between the ⁸⁹Sr and DIC, practitioners should be alert to complications associated with the primary disorder which might occur at a time to raise concern about the intervention.

Key Words: prostatic neoplasms • disseminated intravascular coagulation • strontium • thrombocytopenia

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