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Meckel's Diverticulum: Possible Detection by Combining Pentagastrin with Histamine H₂ Receptor Blocker

Division of Nuclear Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania

Correspondence: For correspondence or reprints contact: Sydney Heyman, MD, Division of Nuclear Medicine, Children's Hospital of Philadelphia, 34th St. and Civic Center Boulevard, Philadelphia, PA 19104.

ABSTRACT

A Meckel's scan was performed on a 7-yr-old boy because of rectal bleeding. He was premedicated with pentagastrin (6 µg/kg subcutaneously) followed by 259 MBq (7 mCi) [^99mTc]pertechnetate intravenously. The study was essentially negative. Because of persistent rectal bleeding and a strong clinical suspicion of a Meckel's, a repeat study was performed 6 wk later. He received pentagastrin as before, but this time was also given a histamine H₂ receptor blocker (zantac). A Meckel's diverticulum was clearly evident.

Key Words: Meckel's diverticulum • pentagastrin

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