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The Journal of Nuclear Medicine Vol. 35 No. 10 1647-1649
© 1994 by Society of Nuclear Medicine
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Uptake of Fluorine-18-Fluorodeoxyglucose in Sarcoidosis

Petra J. Lewis and Alan Salama

The Clinical PET Centre, Guy's & St. Thomas' Hospital and Department of Thoracic Medicine, Guy's Hospital, London

Correspondence: For correspondence or reprints contact: Dr. Petra Lewis, The Clinical PET Centre, Lower Ground Floor, Lambeth Wing, St Thomas' Hospital, Lambeth Palace Rd., London SE1 7EH, England.

ABSTRACT

Whole-body PET scanning was performed using 18F-fluoro-deoxyglucose (FDG) in two patients with hilar lymphadenopathy in whom the clinical differential diagnosis was between sarcoidosis and lymphoma. Both patients were later proven to have sarcoidosis. Uptake of 18FDG was seen in both intra-and extrathoracic lesions as well as in associated erythema nodosum. One patient underwent a repeat scan after steroid therapy where a marked decrease in hilar uptake was seen. Fluorlne-18-fluorodeoxyglucose uptake is observed in lymph nodes with sarcoid involvement. Further investigation is necessary to assess if quantitative differences exist between sarcoid and malignant lymphadenopathy.

Key Words: sarcoidosis • fluorine-18-fluorodeoxyglucose • lymphadenopathy




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