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A Retrospective Study of the Diagnostic Accuracy of a Community Hospital-Based PET Center for the Detection of Coronary Artery Disease Using Rubidium-82

Saint Joseph's Hospital PET Center, Atlanta, Georgia
University of Texas Medical School, Houston, Texas
Kennestone PET Center, Marietta, Georgia

Correspondence: For correspondence or reprints contact: Nizar A. Mullani, Division of Cardiology, Suite 4.258, University of Texas Medical School, 6431 Fannin St., Houston, TX 77025.

ABSTRACT

A retrospective analysis has been earned out to determine the diagnostic accuracy of PET of the heart with ⁸²Rb at a community hospital based center. Methods: Utilization statistics were derived from a total of 1460 patients scanned for the first 36 mo of the center's operation. Diagnostic accuracy for detection of coronary artery disease (CAD) was assessed using three readers blinded to the clinical information. A total of 287 rest and dipyridamole-stress scans of patients who had coronary angiograms within 6 mo of the PET scan were selected by the computer for this study. Each rest/stress scan was read by at least two of the three readers. Results: The average sensitivity for all three readers was 87% for greater than 67% diameter stenosis and the average specificity was 88% for myocardial regions perfused by normal coronary arteries. The average accuracy was 88% for patients with greater than 67% diameter stenosis. Sensitivity and accuracy improved to 92% and 91% respectively for stenosis greater than 90% in diameter. Conclusion: These results compare well with published results from major hospital-based centers and the recently published results from a private PET center in Georgia.

Key Words: PET • rubidium-82 • coronary artery disease • sensitivity • specificity • accuracy • PET utilization

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