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Accumulation of 2-Deoxy-2[¹⁸F]Fluoro-D-Glucose in Human Cancers Heterotransplanted in Nude Mice: Comparison Between Histology and Glycolytic Status

Department of Clinical Oncology, Department of Pathology, Institute of Development, Aging and Cancer, and Cyclotron and Radioisotope Center, Tohoku University, Sendai, Japan

Correspondence: For correspondence or reprints contact: Takashi Yoshioka, MD, Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, 4-1, Seiryo-machi, Aoba-ku, Sendai, 980, Japan (Tel 022-274-1111 ext. 3445).

ABSTRACT

The success of tumor imaging with PET and 2-deoxy-2-fluoro[¹⁸F]-D-glucose (¹⁸FDG) is based on preferential accumulation of ¹⁸FDG in tumors. Methods: Fluorine-18-FDG uptake was measured in nine human cancers heterotransplanted in nude mice and compared with histologic subclassification. Results: Mean ¹⁸FDG uptake by the human cancers was considerably less than that by the host's heart, but values at 60 min after injection were about 2.5 times as high as the liver and kidney, about two times as that for the muscle and about six times that for the blood. Comparison of ¹⁸FDG uptake and histological grade in four gastric, two pancreatic and three colonic cancers showed that ¹⁸FDG uptake increased with loss of differentiation. Conclusion: This nude mice model system is useful for studying correlations between physiological and morphological parameters of heterotransplanted human cancers.

Key Words: fluorine-18-2DG deoxyglucose • nude mice • human cancer

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				T. Yoshioka, K. Yamaguchi, K. Kubota, T. Saginoya, T. Yamazaki, T. Ido, G. Yamaura, H. Takahashi, H. Fukuda, and R. Kanamaru Evaluation of 18F-FDG PET in Patients with Advanced, Metastatic, or Recurrent Gastric Cancer J. Nucl. Med., May 1, 2003; 44(5): 690 - 699. [Abstract] [Full Text] [PDF]