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Positron Emission Tomography with Fluorine-18-Fluorodeoxyglucose for the Evaluation of Therapeutic Isolated Regional Limb Perfusion in a Patient with Soft-Tissue Sarcoma

Department of Surgery, Division of Surgical Oncology and National PET Research Center, University Hospital Groningen, Groningen, The Netherlands

Correspondence: For correspondence and reprints contact: O.E. Nieweg, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

ABSTRACT

Methods: The treatment of a patient with soft-tissue sarcoma was evaluated with FDG-PET. A limb-saving complete remission of a locally advanced liposarcoma of the left thigh was achieved with isolated regional perfusion of the limb with tumor necrosis factor alpha, interferon gamma and melphalan. Results: PET with ¹⁸F-FDG before perfusion showed high glucose consumption in the tumor. After perfusion, glucose metabolism in the tumor was absent. Subsequent excision confirmed complete necrosis of the tumor. Conclusion: FDG-PET may be useful in evaluating the results of isolateral regional limb perfusion for soft-tissue sarcomas.

Key Words: fluorine-18-fluorodeoxyglucose • positron emission tomography • glucose metabolism • isolated limb perfusion • sarcoma

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