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Lung Tumor Metastasis to Breast Detected by Fluorine-18-Fluorodeoxyglucose PET

Department of Radiology, PET Center and Department of Radiation Oncolology, Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For correspondence or reprints contact: Dr. George J. Hunter, Dept. of Radiology, MGH-NMR Center, Massachusetts General Hospital, Building 149, 13th St., Charlestown Navy Yard, Boston, MA 02129.

ABSTRACT

We report a case of breast metastasis from a large-cell bronchogenic adenocarcinoma. Serial ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) was used to monitor the response of the primary lesion to radiation therapy. In the 7-wk interval between studies, an area of markedly increased FDG uptake appeared in the right breast. On subsequent biopsy this proved to be a metastatic deposit from the primary lesion, breast metastasis is uncommon. The ability of FDG-PET to detect metastatic lesions from primary lung tumor is variable. In this case, the finding of the new breast lesion resulted in introduction of chemotherapy to the treatment program.