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Detection and Correction of Patient Motion in Dynamic and Static Myocardial SPECT Using a Multi-Detector Camera

Department of Medical Physics and Imaging, Division of Nuclear Cardiology, Department of Medicine, and Division of Nuclear Medicine, Department of Imaging, Cedars-Sinai Research Institute, Cedars-Sinai Medical Center
Division of Nuclear Medicine, Department of Radiological Sciences, and Department of Medicine, UCLA School of Medicine, Los Angeles, California

Correspondence: For correspondence and reprints contact: Guido Germano, PhD, Director, Nuclear Medicine Physics, Cedars-Sinai Medical Center A047 N, 8700 Beverly Blvd., Los Angeles, CA 90048.

ABSTRACT

We have developed a method for the detection and correction of translational patient motion in dynamic and static myocardial SPECT studies. The method uses a low activity ^99mTc point source and is especially designed for multi-detector cameras. The source's centroid coordinates are measured or derived for all projection images in a temporal frame. The coordinate curves fitted to predicted distributions and the projection images shifted to realign measured to fitted values, with sub-pixel accuracy. In dynamic studies, the frame with the best fits serves as reference for all others. The accuracy of this method, measured with cardiac phantom experiments, was found to be ±0.37 mm and ±0.44 mm in the axial and transaxial dimension, respectively. By comparison, overall motion in 42 patients undergoing ^99mTc-teboroxime dynamic cardiac SPECT studies was ±1.6 mm and ±1.2 mm, respectively (average on 39,272 projection views). Application of the method to phantom experiments, ^99mTc-sestamibi and ^99mTc-teboroxime human studies visually eliminated artifactual perfusion defects from simulated phantom motion and actual patient motion.

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				N. Matsumoto, D. S. Berman, P. B. Kavanagh, J. Gerlach, S. W. Hayes, H. C. Lewin, J. D. Friedman, and G. Germano Quantitative Assessment of Motion Artifacts and Validation of a New Motion-Correction Program for Myocardial Perfusion SPECT J. Nucl. Med., May 1, 2001; 42(5): 687 - 694. [Abstract] [Full Text]