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Evaluation of Indium-111-Polyclonal Immunoglobulin G to Quantitate Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits with Scintigraphy: Effect of Age and Treatment with Antioxidants or Ethinylestradiol

Departments of General Internal Medicine and Nuclear Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands

Correspondence: For reprints or correspondence contact: P.N.M. Demacker, PhD, Department of Medicine, Division of General Internal Medicine, University Hospital Nijmegen, P.O. Box 9101, The Netherlands.

ABSTRACT

Scintigraphic detection of atherosclerotic lesions using ¹¹¹In-polyclonal IgG was studied. In Watanabe heritable hyperlipidemic (WHHL) rabbits, an animal model for hypercholesterolemia with spontaneous atherosclerosis, aged WHHL rabbits incorporated more ¹¹¹In-IgG into atherosclerotic lesions than young WHHL or control NZW rabbits. This result is in agreement with histological analysis. However, due to the low ratio of lesion-incorporated radioactivity to circulating radioactivity, in vivo gamma imaging of atherosclerosis with ¹¹¹In-IgG scintigraphy was unsuccessful. Interventional agents, Probucol or vitamin E, used for 28 days to reduce the amount of autoantibodies produced against biological modified low-density lipoproteins did not produce differences in ¹¹¹In-IgG incorporation into the aorta ex vivo. Ethinylestradiol, used for 28 days, exhibited similar incorporation with decreased serum cholesterol by 45%. Although atherosclerosis histology and lesion surfaces of WHHL rabbits are similar to those in adult humans, it is obvious that noninvasive gamma imaging with polyclonal ¹¹¹In scintigraphy is not reliable for serial evaluation of the extent of atherosclerosis. Our results emphasize the need to develop pharmaceuticals to image atherosclerosis.

FOOTNOTES

^* Present address: Department of Internal Medicine, Sint Joseph Hospital, Veldhoven, The Netherlands.

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