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Distribution of Deoxyglucose and Technetium-99m-Glucarate in the Acutely Ischemic Myocardium

Division of Nuclear Medicine, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts

Correspondence: For correspondence or reprints contact: Alan J. Fischman, MD, PhD, Division of Nuclear Medicine, Massachusetts General Hospital, 32 Fruit St., Boston, MA 02114.

ABSTRACT

The regional myocardial distribution of ^99mTc-glucarate was compared to ³H-deoxyglucose in 22 rabbits with left circumflex marginal artery occlusion. In 12 rabbits, tissue radioactivity measurements were compared to the results of triphenyl tetrazolium chloride staining and light microscopy. In 10 additional rabbits, the myocardial sodium space (²⁴NaCl), an indicator of tissue edema induced by injury, was compared to the distribution of deoxyglucose and glucarate. Technetium-99m-glucarate accumulated in injured myocardium within 6 hr after coronary ligation and myocardial concentration was greatest in the most severely injured zones (TTC unstained). Hydrogen-3-deoxyglucose behaved as a marker of ischemia but concentrated in tissue with injury ranging from mild ischemia (TTC stained) to transmural infarction (TTC unstained). Both ^99mTc-glucarate and ³H-deoxyglucose concentrated in acute, severely injured myocardial tissue. These studies suggest that ^99mTc-glucarate is a useful tracer for evaluating myocardial injury. In addition, it appears that ^99mTc-glucarate and ³H-deoxyglucose demarcate different points in the spectrum of myocardial injury.

FOOTNOTES

Note: Review of this manuscript was made under the supervision of Guest Editor Michael J. Welch, Mallinckrodt Institute of Radiology, Washington University Medical Center, St Louis, MO.

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