HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Peltier, P. Articles by Delaage, M. Search for Related Content PubMed PubMed Citation Articles by Peltier, P. Articles by Delaage, M.

Radioimmunodetection of Medullary Thyroid Cancer Using a Bispecific Anti-CEA/Anti-Indium-DTPA Antibody and an Indium-111-Labeled DTPA Dimer

Nuclear Medicine Department, Centre Rene Gauducheau, Nantes, France
INSERM U211, Nantes, France
Immunotech SA, Marseille, France
DAMRI, Saclay, France
Anatomopatology Department, Nantes, France
Pasteur Institut, Lille, France

Correspondence: For correspondence or reprints contact: Patrick Peltier, MD, Service de Médecine Nucléaire, Hotel Dieu, CHU de Nantes, place Ricordeau, 44035 Nantes Cedex 01, France.

ABSTRACT

Two-step radioimmunotargeting using a bispecific anti-CEA/anti-In-DTPA monoclonal antibody and an ¹¹¹In-labeled DTPA dimer (diDTPA-TL) was evaluated nine times in eight patients with medullary thyroid cancer (MTC). Immunoscintigraphy was performed 5 and 24 hr after injection of ¹¹¹In-diDTPA-TL. For five patients, radioimmunoguided surgery (RIGS) was performed using a hand-hold gamma probe (sodium iodine), and a biodistribution study was performed 48 hr (four times) and 24 hr (one time) after injection of ¹¹¹In-diDTPA-TL. Mean tumor uptake (%ID/kg in tumor) was 39 (range 2.75–139). In these five patients, immunoscintigraphy visualized all known tumors and detected unknown foci (US and CT were negative) in the neck (once) and neck and liver (once). Immunoscintigraphy, performed four times in search of a recurrence, detected unknown localizations in the mediastinum and neck (twice) and was negative twice. There were no false-positives. In three of five patients who had surgery, RIGS localized tumor foci not detected by the surgeon. RIGS failed to detect two small lesions (10 x 10 mm) corresponding to sites of fibrosis and microscopic cancer infiltration. Bispecific anti-CEA/anti-In-DTPA mediated targeting of ¹¹¹In-diDTPA-TL provided elevated tumor uptake and tumor-to-normal tissue ratios. Radioimmunodetection of small MTC lesions is thus possible even when morphological imaging techniques prove negative.

This article has been cited by other articles:

				R. M. Sharkey, H. Karacay, W. J. McBride, E. A. Rossi, C.-H. Chang, and D. M. Goldenberg Bispecific Antibody Pretargeting of Radionuclides for Immuno Single-Photon Emission Computed Tomography and Immuno Positron Emission Tomography Molecular Imaging: An Update Clin. Cancer Res., September 15, 2007; 13(18): 5577s - 5585s. [Abstract] [Full Text] [PDF]

				R. M. Sharkey, G. Hajjar, D. Yeldell, A. Brenner, J. Burton, A. Rubin, and D. M. Goldenberg A Phase I Trial Combining High-Dose 90Y-Labeled Humanized Anti-CEA Monoclonal Antibody with Doxorubicin and Peripheral Blood Stem Cell Rescue in Advanced Medullary Thyroid Cancer J. Nucl. Med., April 1, 2005; 46(4): 620 - 633. [Abstract] [Full Text] [PDF]

				R. M. Sharkey and D. M. Goldenberg Perspectives on Cancer Therapy with Radiolabeled Monoclonal Antibodies J. Nucl. Med., January 1, 2005; 46(1_suppl): 115S - 127S. [Abstract] [Full Text] [PDF]

				T. M. Cardillo, H. Karacay, D. M. Goldenberg, D. Yeldell, C.-H. Chang, D. E. Modrak, R. M. Sharkey, and D. V. Gold Improved Targeting of Pancreatic Cancer: Experimental Studies of a New Bispecific Antibody, Pretargeting Enhancement System for Immunoscintigraphy Clin. Cancer Res., May 15, 2004; 10(10): 3552 - 3561. [Abstract] [Full Text] [PDF]

				O. C. Boerman, F. G. van Schaijk, W. J.G. Oyen, and F. H.M. Corstens Pretargeted Radioimmunotherapy of Cancer: Progress Step by Step J. Nucl. Med., March 1, 2003; 44(3): 400 - 411. [Abstract] [Full Text] [PDF]

				S. Szakall Jr., O. Esik, G. Bajzik, I. Repa, G. Dabasi, I. Sinkovics, P. Agoston, and L. Tron 18F-FDG PET Detection of Lymph Node Metastases in Medullary Thyroid Carcinoma J. Nucl. Med., January 1, 2002; 43(1): 66 - 71. [Abstract] [Full Text] [PDF]

				C. de Labriolle-Vaylet, P. Cattan, E. Sarfati, M. Wioland, C. Billotey, C. Brochériou, E. Rouvier, A. de Roquancourt, W. Rostène, S. Askienazy, et al. Successful Surgical Removal of Occult Metastases of Medullary Thyroid Carcinoma Recurrences with the Help of Immunoscintigraphy and Radioimmunoguided Surgery Clin. Cancer Res., February 1, 2000; 6(2): 363 - 371. [Abstract] [Full Text]